The molecular phylogeny of eph receptors and ephrin ligands

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dc.contributor.authorMellott, Dan O
dc.contributor.authorBurke, Robert D
dc.date.accessioned2014-08-08T18:33:00Z
dc.date.available2014-08-08T18:33:00Z
dc.date.copyright2008en_US
dc.date.issued2008-05-21
dc.descriptionBioMed Centralen_US
dc.description.abstractBackground: The tissue distributions and functions of Eph receptors and their ephrin ligands have been well studied, however less is known about their evolutionary history. We have undertaken a phylogenetic analysis of Eph receptors and ephrins from a number of invertebrate and vertebrate species. Results: Our findings indicate that Eph receptors form three major clades: one comprised of nonchordate and cephalochordate Eph receptors, a second comprised of urochordate Eph receptors, and a third comprised of vertebrate Eph receptors. Ephrins, on the other hand, fall into either a clade made up of the non-chordate and cephalochordate ephrins plus the urochordate and vertebrate ephrin-Bs or a clade made up of the urochordate and vertebrate ephrin-As. Conclusion: We have concluded that Eph receptors and ephrins diverged into A and B-types at different points in their evolutionary history, such that primitive chordates likely possessed an ancestral ephrin-A and an ancestral ephrin-B, but only a single Eph receptor. Furthermore, ephrin- As appear to have arisen in the common ancestor of urochordates and vertebrates, whereas ephrin-Bs have a more ancient bilaterian origin. Ancestral ephrin-B-like ligands had transmembrane domains; as GPI anchors appear to have arisen or been lost at least 3 times.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by grants to RDB from NSERC and CIHR (Canada).en_US
dc.identifier.citationMellott and Burke. The molecular phylogeny of eph receptors and ephrin ligands. BMC Cell Biology 2008, 9:27en_US
dc.identifier.urihttp://www.biomedcentral.com/1471-2121/9/27
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2121-9-27
dc.identifier.urihttp://hdl.handle.net/1828/5537
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subject.departmentDepartment of Biology
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleThe molecular phylogeny of eph receptors and ephrin ligandsen_US
dc.typeArticleen_US

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