Microfluidic-Based Multi-Organ Platforms for Drug Discovery

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dc.contributor.authorKolahchi, Ahmad Rezaei
dc.contributor.authorMohtaram, Nima Khadem
dc.contributor.authorModarres, Hassan Pezeshgi
dc.contributor.authorMohammadi, Mohammad Hossein
dc.contributor.authorGeraili, Armin
dc.contributor.authorJafari, Parya
dc.contributor.authorAkbari, Mohsen
dc.contributor.authorSanati-Nezhad, Amir
dc.date.accessioned2019-01-07T20:05:56Z
dc.date.available2019-01-07T20:05:56Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractDevelopment of predictive multi-organ models before implementing costly clinical trials is central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality. Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro- and nanotechnology, and in silico modeling have enabled single- and multi-organ platforms for investigation of new chemical agents and tissue-tissue interactions. This review provides an overview of the principles of designing microfluidic-based organ-on-chip models for drug testing and highlights current state-of-the-art in developing predictive multi-organ models for studying the cross-talk of interconnected organs. We further discuss the challenges associated with establishing a predictive body-on-chip (BOC) model such as the scaling, cell types, the common medium, and principles of the study design for characterizing the interaction of drugs with multiple targets.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by the Natural Sciences and Engineering Research Council of Canada, and Alberta Innovates-Bio Solutions.en_US
dc.identifier.citationKolahchi, A.R., Mohtaram, N.K., Modarres, H.P., Mohammadi, M.H., Geraili, A., Jafari, P., Akbari, M. & Sanati-Nezhad, A. (2016). Microfluidic-Based Multi-Organ Platforms for Drug Discovery. Micromachines, 7(9), 162. https://doi.org/10.3390/mi7090162en_US
dc.identifier.urihttps://doi.org/10.3390/mi7090162
dc.identifier.urihttp://hdl.handle.net/1828/10489
dc.language.isoenen_US
dc.publisherMicromachinesen_US
dc.subjectdrug discovery
dc.subjectbody-on-chip
dc.subjectmicrofluidics
dc.subjectorgan-on-chip
dc.subjectin silico modeling
dc.subject.departmentDepartment of Mechanical Engineering
dc.titleMicrofluidic-Based Multi-Organ Platforms for Drug Discoveryen_US
dc.typeArticleen_US

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