Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability
| dc.contributor.author | Bush, Jason R. | |
| dc.contributor.author | Han, Jun | |
| dc.contributor.author | Deehan, Edward C. | |
| dc.contributor.author | Harding, Scott V. | |
| dc.contributor.author | Maiya, Madhura | |
| dc.contributor.author | Baisley, Joshua | |
| dc.contributor.author | Schibli, David | |
| dc.contributor.author | Goodlett, David R. | |
| dc.date.accessioned | 2023-10-06T14:01:06Z | |
| dc.date.available | 2023-10-06T14:01:06Z | |
| dc.date.copyright | 2023 | en_US |
| dc.date.issued | 2023 | |
| dc.description.abstract | Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in participants consuming 3.5 g/day RPS or placebo (n = 48) was performed using liquid chromatography-mass spectrometry to determine whether RPS positively influences histamine metabolism and related parameters. Histamine levels were significantly reduced by RPS treatment, but histamine-degrading enzyme products were unaffected by RPS. RPS also reduced histamine-secreting Haemophilus and Lactobacillus. Further, metabolites associated with intestinal permeability, including 5-hydroxylysine, acetylspermidine, and short- and medium-chain carnitines ratios, were significantly reduced by RPS treatment, suggesting decreased serum histamine might be related to enhanced gut barrier function. These metabolomic findings expand the value of supplementing the diet with RPS. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | This work was supported by Canadian Agricultural Partnership- AgAction Manitoba [Task number 1000227239] and MSP Starch Products Inc., Carberry, MB, Canada. Work performed at the University of Victoria-Genome BC Proteomics Centre was supported by funding to The Metabolomics Innovation Centre from Genome Canada and Genome British Columbia, through the Genomics Technology Platform and Genomics Innovation Network programs for operations and technology development [grant numbers 265MET, 215MET, 205MET and MC3T], as well operational support from the Canadian Foundation for Innovation - Major Sciences Initiative program [grant number 35456]. | en_US |
| dc.identifier.citation | Bush, J.R., Han, J., Deehan, E.C., Harding, S.V., Maiya, M., Baisley, J., Schibli, D., & Goodlett, D. R. (2023). Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability. Journal of Functional Foods, 108, 105740. https://doi.org/10.1016/j.jff.2023.105740. | en_US |
| dc.identifier.uri | https://doi.org/10.1016/j.jff.2023.105740 | |
| dc.identifier.uri | http://hdl.handle.net/1828/15481 | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Functional Foods | en_US |
| dc.subject | Prebiotic | |
| dc.subject | Resistant starch | |
| dc.subject | Histamine | |
| dc.subject | Hydroxylysine | |
| dc.subject | Intestinal permeability | |
| dc.subject | Polyamine | |
| dc.subject | Beta-oxidation | |
| dc.subject | UVic Genome BC Proteomics Centre | |
| dc.subject.department | Division of Medical Sciences | |
| dc.subject.department | School of Medical Sciences | |
| dc.subject.department | Department of Biochemistry and Microbiology | |
| dc.title | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability | en_US |
| dc.type | Article | en_US |