Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases?
| dc.contributor.author | Yau, Sonata Suk Yu | |
| dc.contributor.author | Gil-Mohapel, Joana | |
| dc.contributor.author | Christie, Brian | |
| dc.contributor.author | So, Kwok-fai | |
| dc.date.accessioned | 2017-11-05T14:17:47Z | |
| dc.date.available | 2017-11-05T14:17:47Z | |
| dc.date.copyright | 2014 | en_US |
| dc.date.issued | 2014-04-09 | |
| dc.description.abstract | Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline. Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involve cognitive impairment. We further discuss how physical exercise may contribute to cognitive improvement in the ageing brain by preserving adult neurogenesis, and review the recent approaches for measuring changes in neurogenesis in the live human brain. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | Suk-yu Yau received a postdoctoral fellowship from the Research Centre of Heart, Brain, Hormone and Healthy Ageing and the Small Project Funding from The University of Hong Kong, Hong Kong. Suk-yu Yau acknowledges the funding from Canadian Institute of Health Research in partnership with Fragile X Research Foundation of Canada. Joana Gil-Mohapel acknowledges the funding from the Ciência Sem Fronteiras funding program (Science Without Borders, Brazil). Brian R. Christie is a Michael Smith Senior Scholar and is supported by grants from the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), the Michael Smith Foundation for Health Research (MSFHR), and the Canada Foundation for Innovation (CFI). Kwok-fai So received funding from Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited), the Fundamental Research Funds for the Central Universities (Grant 21609101). | en_US |
| dc.identifier.citation | Yau, S., Gil-Mohapel, J., Christie, B.R., & So, K. (2014). Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases? BioMed Research International, Vol. 2014, Article ID 403120. | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1155/2014/403120 | |
| dc.identifier.uri | http://hdl.handle.net/1828/8782 | |
| dc.language.iso | en | en_US |
| dc.publisher | BioMed Research International | en_US |
| dc.subject.department | Division of Medical Sciences | |
| dc.subject.department | School of Medical Sciences | |
| dc.title | Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases? | en_US |
| dc.type | Article | en_US |