HIV Treatment Optimism and Crystal Methamphetamine Use and Initiation Among HIV-Negative Men Who Have Sex With Men in Vancouver, Canada: A Longitudinal Analysis

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dc.contributor.authorColyer, Sean P.
dc.contributor.authorLachowsky, Nathan J.
dc.contributor.authorCui, Zishan
dc.contributor.authorZhu, Julia
dc.contributor.authorArmstrong, Heather L.
dc.contributor.authorTaylor, Matthew
dc.contributor.authorEdward, Joshua
dc.contributor.authorOlarewaju, Gbolahan
dc.contributor.authorHogg, Robert S.
dc.contributor.authorRoth, Eric A.
dc.contributor.authorMoore, David M.
dc.date.accessioned2022-06-16T23:38:33Z
dc.date.available2022-06-16T23:38:33Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.descriptionWe would like to thank the Momentum Health Study participants, office staff, community advisory board, and our community agency partners: Health Initiative for Men, YouthCO HIV & Hep C Society, and Positive Living Society of BC.en_US
dc.description.abstractBackground: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation. Methods: Using data from a prospective behavioural cohort study of sexually-active MSM in the Vancouver area, we used multi-level generalized mixed effect models to evaluate temporal trends in CM use, univariable and multivariable logistic regression to identify covariates of recent CM use, and univariable and multivariable survival analysis to identify predictors of CM initiation. Results: Of 497 HIV-negative cohort participants, 10.3% reported any recent CM use at enrollment. From 2012-2016, there were no statistically significant temporal trends in overall CM use or with routes of administration. In multivariable logistic regression analyses, HIV treatment optimism was not associated with recent CM use (not retained in final model) or CM initiation (aHR=1.06, 95% CI:0.98-1.15). Significant correlates of CM use include recent gamma-hydroxybutyrate (GHB) and ecstasy use, and having received/given drugs for sex. Conclusions: Among HIV-negative MSM in Vancouver, HIV treatment optimism does not appear to be independently associated with CM use or initiation of use, though use of CM was both prevalent and stable over time.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by the National Institute on Drug Abuse (R01DA031055-01A1) and the Canadian Institutes of Health Research (MOP-107544, 143342, PJT-153139). We would also like to thank Biolytical Laboratories who provided the HIV test kits. NJL was supported by a CANFAR/CTN Postdoctoral Fellowship Award. HLA is supported by a Postdoctoral Fellowship Award from the Canadian Institutes of Health Research (Grant # MFE-152443). DMM and NJL are supported by Michael Smith Foundation for Health Research Scholar Awards (#5209, #16863).en_US
dc.identifier.citationColyer, S. P., Lachowsky, N. J., Cui, Z., Zhu, J., Armstrong, H. L., Taylor, M., Edward, J., Olarewaju, G., Hogg, R. S., Roth, E. A., & Moore, D. M. (2018). “HIV Treatment Optimism and Crystal Methamphetamine Use and Initiation Among HIVNegative Men Who Have Sex With Men in Vancouver, Canada: A Longitudinal Analysis.” Drug and Alcohol Dependence, 185, 67-74. https://doi.org/10.1016/j.drugalcdep.2017.12.004en_US
dc.identifier.urihttps://doi.org/10.1016/j.drugalcdep.2017.12.004
dc.identifier.urihttp://hdl.handle.net/1828/13985
dc.language.isoenen_US
dc.publisherDrug and Alcohol Dependenceen_US
dc.subjectHIV/AIDS
dc.subjectmethamphetamine
dc.subjectmen who have sex with men (MSM)
dc.subjectgay and bisexual men
dc.subjectHIV treatment optimism
dc.subjecttreatment as prevention (TasP)
dc.subject.departmentSchool of Public Health and Social Policy
dc.subject.departmentDepartment of Anthropology
dc.titleHIV Treatment Optimism and Crystal Methamphetamine Use and Initiation Among HIV-Negative Men Who Have Sex With Men in Vancouver, Canada: A Longitudinal Analysisen_US
dc.typePostprinten_US

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