The Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Development

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dc.contributor.authorErickson, Anders C.
dc.contributor.authorArbour, Laura
dc.date.accessioned2017-11-05T13:57:41Z
dc.date.available2017-11-05T13:57:41Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.description.abstractExposure to particulate air pollution and socioeconomic risk factors are shown to be independently associated with adverse pregnancy outcomes; however, their confounding relationship is an epidemiological challenge that requires understanding of their shared etiologic pathways affecting fetal-placental development. The purpose of this paper is to explore the etiological mechanisms associated with exposure to particulate air pollution in contributing to adverse pregnancy outcomes and how these mechanisms intersect with those related to socioeconomic status. Here we review the role of oxidative stress, inflammation and endocrine modification in the pathoetiology of deficient deep placentation and detail how the physical and social environments can act alone and collectively to mediate the established pathology linked to a spectrum of adverse pregnancy outcomes. We review the experimental and epidemiological literature showing that diet/nutrition, smoking, and psychosocial stress share similar pathways with that of particulate air pollution exposure to potentially exasperate the negative effects of either insult alone. Therefore, socially patterned risk factors often treated as nuisance parameters should be explored as potential effect modifiers that may operate at multiple levels of social geography. The degree to which deleterious exposures can be ameliorated or exacerbated via community-level social and environmental characteristics needs further exploration.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was funded by a Canadian Institute of Health Research Grant (IPH-98849). Dr. Arbour is also funded through a Michael Smith Foundation for Health Research Salary Award. Funders provided no role in the direction of this review paper.en_US
dc.identifier.citationErickson, A.C., & Arbour, L. (2014). The Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Development. Journal of Environmental and Public Health, Vol. 2014, Article ID 901017.en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2014/901017
dc.identifier.urihttp://hdl.handle.net/1828/8775
dc.language.isoenen_US
dc.publisherJournal of Environmental and Public Healthen_US
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleThe Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Developmenten_US
dc.typeArticleen_US

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