Recent Hits Acquired by BLAST (ReHAB): A tool to identify new hits in sequence similarity searches

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dc.contributor.authorWhitney, Joe
dc.contributor.authorEsteban, David J
dc.contributor.authorUpton, Chris
dc.date.accessioned2015-07-06T18:18:26Z
dc.date.available2015-07-06T18:18:26Z
dc.date.copyright2005en_US
dc.date.issued2005-02-08
dc.descriptionBioMedCentralen_US
dc.description.abstractBackground: Sequence similarity searching is a powerful tool to help develop hypotheses in the quest to assign functional, structural and evolutionary information to DNA and protein sequences. As sequence databases continue to grow exponentially, it becomes increasingly important to repeat searches at frequent intervals, and similarity searches retrieve larger and larger sets of results. New and potentially significant results may be buried in a long list of previously obtained sequence hits from past searches. Results: ReHAB (Recent Hits Acquired from BLAST) is a tool for finding new protein hits in repeated PSI-BLAST searches. ReHAB compares results from PSI-BLAST searches performed with two versions of a protein sequence database and highlights hits that are present only in the updated database. Results are presented in an easily comprehended table, or in a BLAST-like report, using colors to highlight the new hits. ReHAB is designed to handle large numbers of query sequences, such as whole genomes or sets of genomes. Advanced computer skills are not needed to use ReHAB; the graphics interface is simple to use and was designed with the bench biologist in mind. Conclusions: This software greatly simplifies the problem of evaluating the output of large numbers of protein database searchesen_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was funded by NIAID/DARPA grant U01 AI48653-02 and Cana- dian NSERC Strategic Grant STPGP 269665-0en_US
dc.identifier.citationWhitney, J et al. BMC Bioinformatics 2005, 6 :23en_US
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2105-6-23
dc.identifier.urihttp://hdl.handle.net/1828/6295
dc.language.isoenen_US
dc.publisherBMC Bioinformaticsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subject.departmentDepartment of Microbiology and Biochemistry
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleRecent Hits Acquired by BLAST (ReHAB): A tool to identify new hits in sequence similarity searchesen_US
dc.typeArticleen_US

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