Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

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dc.contributor.authorAskari, Esfandyar
dc.contributor.authorSeyfoori, Amir
dc.contributor.authorAmereh, Meitham
dc.contributor.authorGharaie, Sadaf Samimi
dc.contributor.authorGhazali, Hanieh Sadat
dc.contributor.authorGhazali, Zahra Sadat
dc.contributor.authorKhunjush, Bardia
dc.contributor.authorAkbari, Mohsen
dc.date.accessioned2020-07-06T17:06:03Z
dc.date.available2020-07-06T17:06:03Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractCurrently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipFunding: This research was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC), grant number RGPIN-2016-04024 and the BC Cancer Foundation. Acknowledgments: We acknowledge the support of the Natural Sciences and Engineering Research Council of Canada (NSERC) the BC Cancer Foundation.en_US
dc.identifier.citationAskhari, E., Seyfoori, S., Amereh, M., Gharaie, S. S., Ghazali, H. S., Ghazali, Z. S., Khunjush, B., & Akbari, M. (2020). Stimuli-responsive hydrogels for local postsurgical drug delivery. Gels, 6(2). https://doi.org/10.3390/gels6020014en_US
dc.identifier.urihttps://doi.org/10.3390/gels6020014
dc.identifier.urihttp://hdl.handle.net/1828/11903
dc.language.isoenen_US
dc.publisherGelsen_US
dc.subjectdrug delivery systems
dc.subjectimplantable
dc.subjectinjectable
dc.subjectsprayable
dc.subjecthydrogel
dc.subjectLaboratory for Innovations in Micro Engineering (LiME)
dc.subjectCentre for Advanced Materials and Related Technology (CAMTEC)
dc.subjectCentre for Biomedical Research
dc.subject.departmentDepartment of Mechanical Engineering
dc.titleStimuli-Responsive Hydrogels for Local Post-Surgical Drug Deliveryen_US
dc.typeArticleen_US

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