Phenol-rich Feijoa sellowiana (pineapple guava) extracts protect human red blood cells from mercury-induced cellular toxicity

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dc.contributor.authorTortora, Fabiana
dc.contributor.authorNotariale, Rosaria
dc.contributor.authorMaresca, Viviana
dc.contributor.authorGood, Katrina V
dc.contributor.authorSorbo, Sergio
dc.contributor.authorBasile, Adriana
dc.contributor.authorPiscopo, Marina
dc.contributor.authorManna, Caterina
dc.date.accessioned2023-01-13T23:27:55Z
dc.date.available2023-01-13T23:27:55Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractPlant polyphenols, with broadly known antioxidant properties, represent very effective agents against environmental oxidative stressors, including mercury. This heavy metal irreversibly binds thiol groups, sequestering endogenous antioxidants, such as glutathione. Increased incidence of food-derived mercury is cause for concern, given the many severe downstream effects, ranging from kidney to cardiovascular diseases. Therefore, the possible beneficial properties of Feijoa sellowiana against mercury toxicity were tested using intact human red blood cells (RBC) incubated in the presence of HgCl2. Here, we show that phenol-rich (10–200 μg/mL) extracts from the Feijoa sellowiana fruit potently protect against mercury-induced toxicity and oxidative stress. Peel and pulp extracts are both able to counteract the oxidative stress and thiol decrease induced in RBC by mercury treatment. Nonetheless, the peel extract had a greater protective effect compared to the pulp, although to a different extent for the different markers analyzed, which is at least partially due to the greater proportion and diversity of polyphenols in the peel. Furthermore, Fejioa sellowiana extracts also prevent mercury-induced morphological changes, which are known to enhance the pro-coagulant activity of these cells. These novel findings provide biochemical bases for the pharmacological use of Fejioa sellowiana-based functional foods in preventing and combating mercury-related illnesses.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationTortora, F., Notariale, R., Maresca, V., Good, K. V., Sorbo, S., Basile, A., . . . Manna, C. (2019). “Phenol-rich Feijoa sellowiana (pineapple guava) extracts protect human red blood cells from mercury-induced cellular toxicity.” Antioxidants, 8(7), 220. https://doi.org/10.3390/antiox8070220en_US
dc.identifier.urihttps://doi.org/10.3390/antiox8070220
dc.identifier.urihttp://hdl.handle.net/1828/14666
dc.language.isoenen_US
dc.publisherAntioxidantsen_US
dc.subjectfeijoa extracts
dc.subjectmercury
dc.subjectred blood cells
dc.subjectoxidative stress
dc.subjectglutathione
dc.subjectthiol groups
dc.subjectfunctional food
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titlePhenol-rich Feijoa sellowiana (pineapple guava) extracts protect human red blood cells from mercury-induced cellular toxicityen_US
dc.typeArticleen_US

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