Analysis of the conservation of synteny between Fugu and human chromosome 12

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dc.contributor.authorMontpetit, Alexandre
dc.contributor.authorWilson, Michael D
dc.contributor.authorChevrette, Mario
dc.contributor.authorKoop, Ben F
dc.contributor.authorSinnett, Daniel
dc.date.accessioned2013-11-27T23:10:53Z
dc.date.available2013-11-27T23:10:53Z
dc.date.copyright2003en_US
dc.date.issued2003-07-23
dc.descriptionBioMed Centralen_US
dc.description.abstractBackground: The pufferfish Fugu rubripes (Fugu) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and Fugu genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified. Results: We investigated approximately 200 kb of the genomic region surrounding the ETV6 locus in Fugu (fETV6) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the fETV6 locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the Fugu and human ETV6 loci. Conclusion: This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact Fugu genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipD.S. is a scholar of the Fonds de la Recherche en Santé du Québec. A.M. has received a studentship from the Canadian Institutes for Health Research (CIHR). M.D.W. is supported by the Michael Smith Foundation for Health Research. This work was supported by grants from the CIHR (D.S. and B.F.K.) and The Canadian Genetic Diseases Network (B.F.K.).en_US
dc.identifier.citationMontpetit A, Wilson MD, Chevrette M, Koop BF, Sinnett D: Analysis of the conservation of synteny between Fugu and human chromosome 12. BMC Genomics 2003, 4en_US
dc.identifier.urihttp://www.biomedcentral.com/1471-2164/4/30
dc.identifier.urihttp://hdl.handle.net/1828/5042
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subjectCentre for Biomedical Research
dc.subject.departmentDepartment of Biology
dc.titleAnalysis of the conservation of synteny between Fugu and human chromosome 12en_US
dc.typeArticleen_US

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