The role of MeCP2 in regulating synaptic plasticity in the context of stress and depression

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dc.contributor.authorSánchez-Lafuente, Carla L.
dc.contributor.authorKalynchuk, Lisa E.
dc.contributor.authorCaruncho, Hector J.
dc.contributor.authorAusió, Juan
dc.date.accessioned2022-10-25T16:32:36Z
dc.date.available2022-10-25T16:32:36Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.description.abstractMethyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant in the brain. It binds to methylated genomic DNA to regulate a range of physiological functions implicated in neuronal development and adult synaptic plasticity. MeCP2 has mainly been studied for its role in neurodevelopmental disorders, but alterations in MeCP2 are also present in stress-related disorders such as major depression. Impairments in both stress regulation and synaptic plasticity are associated with depression, but the specific mechanisms underlying these changes have not been identified. Here, we review the interplay between stress, synaptic plasticity, and MeCP2. We focus our attention on the transcriptional regulation of important neuronal plasticity genes such as BDNF and reelin (RELN). Moreover, we provide evidence from recent studies showing a link between chronic stress-induced depressive symptoms and dysregulation of MeCP2 expression, underscoring the role of this protein in stress-related pathology. We conclude that MeCP2 is a promising target for the development of novel, more efficacious therapeutics for the treatment of stress-related disorders such as depression.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by a grant from the Ontario Rett Syndrome Association (ORSA) and by a grant from the Canadian Institutes of Health Research; (CIHR grant MOP-130417) to JA.en_US
dc.identifier.citationSánchez-Lafuente, C., Kalynchuk, L., Caruncho, H., & Ausió, J. (2022). “The role of MeCP2 in regulating synaptic plasticity in the context of stress and depression.” Cells, 11(4), 748. https://doi.org/10.3390/cells11040748en_US
dc.identifier.urihttps://doi.org/10.3390/cells11040748
dc.identifier.urihttp://hdl.handle.net/1828/14314
dc.language.isoenen_US
dc.publisherCellsen_US
dc.subjectmethyl-CpG-binding protein 2 (MeCP2)
dc.subjectepigenetics
dc.subjectreelin
dc.subjectdepression
dc.subjectstress
dc.subjectsynaptic plasticity
dc.subjectbrain-derived neurotrophic factor (BDNF)
dc.subjecttranscriptional repression
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleThe role of MeCP2 in regulating synaptic plasticity in the context of stress and depressionen_US
dc.typeArticleen_US

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