Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non‑reproductive periods

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dc.contributor.authorLuz, J.S.
dc.contributor.authorCaneguim, B.H.
dc.contributor.authorBaggio, A.
dc.contributor.authorSantoni, M.M.
dc.contributor.authorHelbing, Caren C.
dc.contributor.authorValentini, S.R.
dc.contributor.authorSasso-Cerri, E.
dc.contributor.authorOliveria, C.C.
dc.date.accessioned2019-04-21T18:14:35Z
dc.date.available2019-04-21T18:14:35Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractObjective: The RNA exosome is an evolutionarily conserved 3′–5′ exoribonucleolytic protein complex involved in processing and degradation of different classes of nuclear and cytoplasmic RNAs, and, therefore, important for the posttranscriptional control of gene expression. Despite the extensive in vivo functional studies and the structural data on the RNA exosome, few studies have been performed on the localization and expression of exosome subunits during gametogenesis, process during which gene expression is largely controlled at the posttranscriptional level. Results We report the identification of exosome subunits in Lithobates catesbeianus and analysis of the differential subcellular localization of RNA exosome core and catalytic subunits in testis cells. In addition, we show seasonal differences in the expression levels of four exosome subunits in different organs. In addition to being part of the RNA exosome complex, its subunits might participate independently of the complex in the control of gene expression during seasonal variation in bullfrog tissues. These results may be relevant for other eukaryotic species.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by a FAPESP grant (2012/51200-7 to J.S.L.; 2012/23845-3 to E.S.C.; 2010/51842-3 to C.C.O.), PADC-FCFar grant (2012/6-I to J.S.L). A. B. was recipient of a FAPESP fellowship (2014/21383-8).en_US
dc.identifier.citationLuz, J.S., Caneguim, B.H., Baggio, A., Santoni, M.M., Helbing, Valentini, S.R., Sasso-Cerri, E. & Oliveira, C.C. (2019). Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and nonreproductive periods BMC Research Notes, 12(46). https://doi.org/10.1186/s13104-019-4077-7en_US
dc.identifier.urihttps://doi.org/10.1186/s13104-019-4077-7
dc.identifier.urihttp://hdl.handle.net/1828/10723
dc.language.isoenen_US
dc.publisherBMC Research Notesen_US
dc.subjectRNA exosome
dc.subjectProtein localization
dc.subjectLithobates catesbeianus
dc.subjectTissue expression
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleDifferential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non‑reproductive periodsen_US
dc.typeArticleen_US

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