Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems
| dc.contributor.author | Gharaie, Sadaf Samimi | |
| dc.contributor.author | Mohammad Hossein Dabiri, Seyed | |
| dc.contributor.author | Akbari, Mohsen | |
| dc.date.accessioned | 2019-01-24T20:25:47Z | |
| dc.date.available | 2019-01-24T20:25:47Z | |
| dc.date.copyright | 2018 | en_US |
| dc.date.issued | 2018 | |
| dc.description.abstract | In this study, we fabricated and characterized a smart shear-thinning hydrogel composed of gelatin and laponite for localized drug delivery. We added chitosan (Chi) and poly N-isopropylacrylamide-co-Acrylic acid (PNIPAM) particles to the shear-thinning gel to render it pH-responsive. The effects of total solid weight and the percentage of laponite in a solid mass on the rheological behavior and mechanical properties were investigated to obtain the optimum formulation. The nanocomposite gel and particles were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zeta potential, and dynamic light scattering techniques. Finally, release related experiment including degradability, swelling and Rhodamine B (Rd) release at various pH were performed. The results suggest that incorporation of silicate nanoplatelets in the gelatin led to the formation of the tunable porous composite, with a microstructure that was affected by introducing particles. Besides, the optimum formulation possessed shear-thinning properties with modified rheological and mechanical properties which preserved its mechanical properties while incubated in physiological conditions. The release related experiments showed that the shear-thinning materials offer pH-sensitive behavior so that the highest swelling ratio, degradation rate, and Rd release were obtained at pH 9.18. Therefore, this nanocomposite gel can be potentially used to develop pH-sensitive systems. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | This research was funded by Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Researches (CIHR), and the Canadian Foundation for Innovations (CFI). M.A. and S.S.G. acknowledge the funding received from Natural Sciences and Engineering Research Council of Canada (NSERC)-Discovery and NSERC-Research Tools and Instruments (RTI) grants for supporting this work. M.A. and S.M.H.D. would like to also thank the support received from the Canadian Institutes of Health Researches (CIHR) for their financial support. M.A. also acknowledges the support of the Canadian Foundation for Innovations (CFI) for funding. | en_US |
| dc.identifier.citation | Gharaie, S.S., Dabiri, S.M.H. & Akbari, M. (2018). Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems. Polymers, 10(12), 1317. https://doi.org/10.3390/polym10121317 | en_US |
| dc.identifier.uri | https://doi.org/10.3390/polym10121317 | |
| dc.identifier.uri | http://hdl.handle.net/1828/10549 | |
| dc.language.iso | en | en_US |
| dc.publisher | Polymers | en_US |
| dc.subject | shear-thinning | |
| dc.subject | hydrogels | |
| dc.subject | pH-responsive | |
| dc.subject | gelatin | |
| dc.subject | laponite | |
| dc.subject | chitosan | |
| dc.subject | N-isopropylacrylamide | |
| dc.subject | nanocomposite | |
| dc.subject | Laboratory for Innovations in Micro Engineering (LiME) | |
| dc.subject | Centre for Advanced Materials and Related Technology (CAMTEC) | |
| dc.subject | Centre for Biomedical Research | |
| dc.subject.department | Department of Mechanical Engineering | |
| dc.title | Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems | en_US |
| dc.type | Article | en_US |