The emerging Pannexin 1 signalome:a new nexus revealed?

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dc.contributor.authorWicki-Stordeur, Leigh E.
dc.contributor.authorSwayne, Leigh Anne
dc.date.accessioned2015-08-25T23:23:50Z
dc.date.available2015-08-25T23:23:50Z
dc.date.copyright2014en_US
dc.date.issued2014-01-08
dc.description.abstractPannexins (Panxs) are a family of single-membrane, large-pore ion, and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many physiological and pathophysiological settings. This channel is widely expressed across various cell and tissue types; however its links to precise signaling pathways are largely unknown. Here we review the current literature surrounding presently identified Panx1–protein interactions, a critical first step to unraveling the Panx1 signalome. First we elucidate the reported associations of Panx1 with other ion channels, receptors, and channel signaling complexes. Further, we highlight recently identified Panx1–cytoskeleton interactions. Finally, we discuss the implications of these protein–protein interactions for Panx1 function in various cell and tissue types, and identify key outstanding questions arising from this work.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipNSERC Discovery Grant; Heart and Stroke Foundation Partnership for Stroke Recovery; Canadian Foundation for Innovation and British Columbia Knowledge Development Fund; NSERC CGSM; Howard E. Petch research scholarship; Edythe Hembroff Schleicher graduate scholarship; Victoria Foundation WIllard and Elva Dawson Fund.en_US
dc.identifier.citationWicki-Stordeur, L. & Swayne, L. 2014, "The emerging Pannexin 1 signalome: a new nexus revealed?", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, article. 287.en_US
dc.identifier.urihttp://dx.doi.org/10.3389/fncel.2013.00287
dc.identifier.urihttp://hdl.handle.net/1828/6556
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.subjectPannexin 1en_US
dc.subjectPanx1en_US
dc.subjectpannexinsen_US
dc.subjectinteractomeen_US
dc.subjectP2X7en_US
dc.subjectinflammasomeen_US
dc.subjectcytoskeletonen_US
dc.titleThe emerging Pannexin 1 signalome:a new nexus revealed?en_US
dc.typeArticleen_US

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