Combining Gold Nanoparticles with Other Radiosensitizing Agents for Unlocking the Full Potential of Cancer Radiotherapy

Simple item page
dc.contributor.authorAlhussan, Abdulaziz
dc.contributor.authorBozdoğan, Ece Pinar Demirci
dc.contributor.authorChithrani, Devika B.
dc.date.accessioned2021-04-03T15:13:00Z
dc.date.available2021-04-03T15:13:00Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractAbout half of cancer patients (50%) receive radiotherapy (RT) for the treatment of local tumors. However, one of the main obstacles in RT is the close proximity of adjacent organs at risk, resulting in treatment doses being limited by significant tissue toxicity, hence preventing the necessary dose escalation that would guarantee local control. Effective local cancer therapy is needed to avoid progression of tumors and to decrease the development of systemic metastases which may further increase the possibility of resection. In an effort to do so, radiosensitizing agents are introduced to further increase damage to the tumor while minimizing normal tissue toxicity. Cisplatin and docetaxel (DTX) are currently being used as radiation dose enhancers in RT. Recent research shows the potential of gold nanoparticles (GNPs) as a radiosensitizing agent. GNPs are biocompatible and have been tested in phase I clinical trials. The focus will be on exploring the effects of adding other radiosensitizing agents such as DTX and cisplatin to the GNP-RT platform. Therefore, a combined use of local radiosensitizing agents, such as GNPs, with currently available radiosensitizing drugs could make a significant impact in future RT. The ultimate goal is to develop treatments that have limited or nonexistent side effects to improve the quality of life of all cancer patients.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipAuthors would like to acknowledge funding from Natural Sciences and Engineering Research Council of Canada, British Columbia Knowledge Development Fund, Canadian Foundation for Innovation, and University of Victoria for their support.en_US
dc.identifier.citationAlhussan, A., Bozdoğan, E. P. D., & Chithrani, D. B. (2021). Combining Gold Nanoparticles with Other Radiosensitizing Agents for Unlocking the Full Potential of Cancer Radiotherapy. Pharmaceutics, 13, 1-17. https://doi.org/10.3390/pharmaceutics13040442.en_US
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics13040442
dc.identifier.urihttp://hdl.handle.net/1828/12827
dc.language.isoenen_US
dc.publisherPharmaceuticsen_US
dc.subjectradiotherapy
dc.subjectgold nanoparticles
dc.subjectcisplatin
dc.subjectdocetaxel
dc.subjectCentre for Advanced Materials and Related Technologies (CAMTEC)
dc.subjectCentre for Biomedical Research
dc.subject.departmentDepartment of Physics and Astronomy
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleCombining Gold Nanoparticles with Other Radiosensitizing Agents for Unlocking the Full Potential of Cancer Radiotherapyen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Alhussan_Abdulaziz_Pharmaceutics_2021.pdf
Size:
2.04 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.