Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes

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dc.contributor.authorJung, Yoon Hee
dc.contributor.authorSauria, Michael E.G.
dc.contributor.authorLyu, Xiaowen
dc.contributor.authorCheema, Majinder S.
dc.contributor.authorAusio, Juan
dc.contributor.authorTaylor, James
dc.contributor.authorCorces, Victor G.
dc.date.accessioned2018-02-26T18:08:22Z
dc.date.available2018-02-26T18:08:22Z
dc.date.copyright2017en_US
dc.date.issued2017
dc.description.abstractThe mammalian sperm genome is thought to lack substantial information for the regulation of future expression after fertilization. Here, we show that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone modifications. Analysis of these modifications suggests that many enhancers and super-enhancers functional in embryonic and adult tissues are already specified in sperm. The sperm genome is bound by CTCF and cohesin at sites that are also present in round spermatids and embryonic stem cells (ESCs). These sites mediate interactions that organize the sperm genome into domains and compartments that overlap extensively with those found in mESCs. These results suggest that sperm carry a rich source of regulatory information, encoded in part by its three-dimensional folding specified by CTCF and cohesin. This information may contribute to future expression during embryonic and adult life, suggesting mechanisms by which environmental effects on the paternal germline are transmitted transgenerationally.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by US Public Health Service Awards (R01 GM035463 to V.G.C. and U41 HG006620 to J.T.) from the National Institutes of Health and Natural Sciences and Engineering Research Council of Canada (NSERC) grant 46399-2012 to J.A.en_US
dc.identifier.citationJung, Y.H., Sauria, M.E.G., Lyu, X., Cheema, M.S., Ausio, J., Taylor, J. & Corces, V.G. (2017). Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes. Cell Reports, 18(6), 1366-1382. http://dx.doi.org/10.1016/j.celrep.2017.01.034en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.celrep.2017.01.034
dc.identifier.urihttp://hdl.handle.net/1828/9097
dc.language.isoenen_US
dc.publisherCell Reportsen_US
dc.subjectchromatin
dc.subjecttranscription
dc.subjectCTCF
dc.subjectTAD
dc.subjectpluripotency
dc.subjectstem cell
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleChromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapesen_US
dc.typeArticleen_US

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