Development of a five degree-of-freedom robot for the manipulation of biological cells

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dc.contributor.authorSakaki, Kelly D.R.
dc.contributor.supervisorPark, E.J.
dc.contributor.supervisorDechev, N
dc.date.accessioned2008-11-20T17:24:47Z
dc.date.available2008-11-20T17:24:47Z
dc.date.copyright2007en_US
dc.date.issued2008-11-20T17:24:47Z
dc.degree.departmentDepartment of Mechanical Engineering
dc.degree.levelMaster of Applied Science M.A.Sc.en_US
dc.description.abstractStudies of individual cells via microscopy and microinjection are a key component in research on gene functions, cancer, stem cells, and reproductive technology. As biomedical experiments become more complex, there is an urgent need for robotic systems to: improve cell manipulation, increase throughput, reduce lost cells, and improve reaction detection. Automation of these tasks using visual servoing creates significant benefits for biomedical laboratories including repeatability of experiments, higher throughput, and a controlled environment capable of operating 24 hours a day. In this work the design and development of a new five degree-of-freedom biomanipulator designed for single-cell microinjection, is described. The biomanipulator employs three degrees of linear motion and two degrees of rotation. This provides the ability to manipulate/micro-inject cells at varying orientations, thereby increasing flexibility in dealing with complex operations such as injecting clustered cells. The capability of the biomanipulator is shown with preliminary experimental results using mouse myeloma cells.en_US
dc.identifier.urihttp://hdl.handle.net/1828/1263
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectbiomanipulatoren_US
dc.subjectmicroscopyen_US
dc.subjectmicroinjectionen_US
dc.subjectbiomedical experimentsen_US
dc.subject.lcshUVic Subject Index::Sciences and Engineering::Engineering::Biomedical engineeringen_US
dc.subject.lcshUVic Subject Index::Sciences and Engineering::Biology::Cellsen_US
dc.subject.lcshUVic Subject Index::Sciences and Engineering::Biology::Geneticsen_US
dc.titleDevelopment of a five degree-of-freedom robot for the manipulation of biological cellsen_US
dc.typeThesisen_US

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