Development of Plasmonic Sensors for Leukemia Diagnosis

Date

2013-04-26

Authors

Valsecchi, Chiara

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Abstract

Plasmonic materials constitute one of the most explored platforms in the past decade for biological sensing, as they offer a wide range of advantages in respect to the currently available tests employed in either screening or medical diagnosis.The detection of leukaemia cancer markers was chosen as the medical applications in the evaluation of the sensing capabilities of these platforms. Particularly, nanohole arrays on gold films have already been demonstrated to be efficientsensing elements for the study of protein – protein interactions. In this work,nanohole arrays platforms were optimized by studying the combinations of shape, diameter, aspect ratio, polarization and periodicity that lead to the highest sensitivity. In addition, different nanohole arrays substrates fabricated by UV-nanolithography and interference lithography were characterized and compared to the structures made by conventional focus ion beam (FIB) milling. Analytes derived from blood sample of leukemia cancer patients were detected on these structures with great sensitivity and specificity, demonstrating a large potential for medical applications. Furthermore, the development and characterization of a cost-effective system capable of detecting leukaemia cancer markers with comparable limit of detection and sensitivity as commercial platforms was started. With future development, this platform could provide advantages in terms of miniaturization, analysis time and the integration as an easy-to-use lab-on-chip device for diagnostics.

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Keywords

nanoholes, spr, biosensor

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