Can the combination of TasP and PrEP eliminate HIV among MSM in British Columbia, Canada?

Date

2021

Authors

Lima, Viviane D.
Zhu, Jielin
Card, Kiffer G.
Lachowsky, Nathan J.
Chowell-Puente, Gerardo
Wu, Zunyou
Montaner, Julio S. G.

Journal Title

Journal ISSN

Volume Title

Publisher

Epidemics

Abstract

Introduction In British Columbia (BC), the HIV epidemic continues to disproportionally affect the gay, bisexual and other men who have sex with men (MSM). In this study, we aimed to evaluate how Treatment as Prevention (TasP) and pre-exposure prophylaxis (PrEP), if used in combination, could lead to HIV elimination in BC among MSM. Methods Considering the heterogeneity in HIV transmission risk, we developed a compartmental model stratified by age and risk-taking behaviour for the HIV epidemic among MSM in BC, informed by clinical, behavioural and epidemiological data. Key outcome measures included the World Health Organization (WHO) threshold for disease elimination as a public health concern and the effective reproduction number (). Model interventions focused on the optimization of different TasP and PrEP components. Sensitivity analysis was done to evaluate the impact of sexual mixing patterns, PrEP effectiveness and increasing risk-taking behaviour. Results The incidence rate was estimated to be 1.2 (0.9–1.9) per 1000 susceptible MSM under the Status Quo scenario by the end of 2029. Optimizing all aspects of TasP and the simultaneous provision of PrEP to high-risk MSM resulted in an HIV incidence rate as low as 0.4 (0.3–0.6) per 1000 susceptible MSM, and an as low as 0.7 (0.6–0.9), indicating that disease elimination was possible when TasP and PrEP were combined. Provision of PrEP to younger MSM or high-risk and younger MSM resulted in a similar HIV incidence rate, but an with credible intervals that crossed one. Conclusion Further optimizing all aspects of TasP and prioritizing PrEP to high-risk MSM can achieve the goal of disease elimination in BC. These results should inform public health policy development and intervention programs that address the HIV epidemic in BC and in other similar settings where MSM are disproportionately affected.

Description

Keywords

MSM, Treatment as Prevention, Pre-exposure prophylaxis, HIV elimination, Mathematical model, British Columbia

Citation

Lima, V. D., Zhu, J., Card, K. G., Lachowsky, N. J., Chowell-Puente, G., Wu, Z., & Montaner, J. S. G. (2021). Can the combination of TasP and PrEP eliminate HIV among MSM in British Columbia, Canada? Epidemics, 35, 1-11. https://doi.org/10.1016/j.epidem.2021.100461.