A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum
| dc.contributor.author | Lithgow, Karen V. | |
| dc.contributor.author | Hof, Rebecca | |
| dc.contributor.author | Wetherell, Charmaine | |
| dc.contributor.author | Phillips, Drew | |
| dc.contributor.author | Houston, Simon | |
| dc.contributor.author | Cameron, Caroline E. | |
| dc.date.accessioned | 2018-07-30T16:03:12Z | |
| dc.date.available | 2018-07-30T16:03:12Z | |
| dc.date.copyright | 2017 | en_US |
| dc.date.issued | 2017-02 | |
| dc.description.abstract | Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high- income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. pallidum. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon T. pallidum challenge compared with unimmunized animals. Introduction of lymph nodes from Tp0751-immunized, T. pallidum-challenged animals to naive animals fails to induce infection, confirming sterile protection. These findings provide evidence that Tp0751 is a promising syphilis vaccine candidate. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | We thank Dr Tara Moriarty, University of Toronto, for assistance with statistical analyses, Brigette Church, University of Victoria, for review of the manuscript, Dr Sheila Lukehart, University of Washington, for critical review of the manuscript and Dr Sheila Lukehart and Barbara Molini, University of Washington, for training on propagation, immunization and challenge procedures as well as lymph node transfer methodology. This work was funded by a Public Health Service Grant from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), to C.E.C under award number R01AI015334. C.E.C. acknowledges the Canada Research Chair program and the Michael Smith Foundation for Health Research Scholar Program for salary support. K.V.L. was supported by a Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship. | en_US |
| dc.identifier.citation | Lithgow, K. V.; Hof, R.; Wetherell, C.; Phillips, D.; Houston, S.; & Cameron, C. E. (2017). A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum. Nature Communications, 8(14273). https://doi.org/10.1038/ncomms14273 | en_US |
| dc.identifier.uri | https://doi.org/10.1038/ncomms14273 | |
| dc.identifier.uri | http://hdl.handle.net/1828/9790 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nature Communications | en_US |
| dc.subject.department | Department of Biochemistry and Microbiology | |
| dc.title | A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum | en_US |
| dc.type | Article | en_US |