Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles

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dc.contributor.authorChen, Ruyao
dc.contributor.authorWulff, Jeremy E.
dc.contributor.authorMoffitt, Matthew G.
dc.date.accessioned2021-06-27T14:41:41Z
dc.date.available2021-06-27T14:41:41Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.description.abstractWe apply gas–liquid microfluidic reactors containing flow-variable, high-shear “hot spots” to produce curcumin-loaded polymer nanoparticles (CUR-PNPs) comprised of poly(caprolactone)-block-poly(ethylene oxide) (PCL-b-PEO) block copolymers at various flow rates and CUR loading ratios. CUR-PNPs prepared using the conventional nanoprecipitation method (bulk method) showed decreased encapsulation efficiency and increased drug precipitation as the loading ratio increased. However, CUR-PNPs prepared by microfluidic manufacturing showed both increased encapsulation efficiency and increased drug loading as either the flow rate or the loading ratio increased. This enabled microfluidic CUR loading percentages of up to 30% to be achieved in this study, which to our knowledge is a record for block copolymer PNPs. As well, it is shown that increased flow rate of microfluidic manufacturing leads to decreased mean CUR-PNP sizes (down to ∼50 nm) and narrower size distributions, along with significantly different CUR release kinetics compared to CUR-PNPs prepared at slower flow rates. In vitro antiproliferation experiments against MDA-MB-231 cells give an average IC50 value of 24 μM for CUR-PNPs compared to 13 μM for free CUR at the same incubation time of 72 h. Compared to conventional bulk and single-phase microfluidic strategies, this unique two-phase reactor represents an exciting manufacturing platform for optimizing polymeric CUR nanomedicines though flow-directed shear processing.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipWe are grateful to the Natural Sciences and Engineering Research Council of Canada, NSERC, for financial support.en_US
dc.identifier.citationChen, R., Wulff, J. E., & Moffitt, M. G. (2018). Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles. Molecular Pharmaceutics, 15(10), 4517-45287. https://doi.org/10.1021/acs.molpharmaceut.8b00529.en_US
dc.identifier.urihttps://doi.org/10.1021/acs.molpharmaceut.8b00529
dc.identifier.urihttp://hdl.handle.net/1828/13071
dc.language.isoenen_US
dc.publisherMolecular Pharmaceuticsen_US
dc.subjectdrug delivery
dc.subjectmicrofluidics
dc.subjectpolymer nanoparticles
dc.subjectcurcumin
dc.subject.departmentDepartment of Chemistry
dc.titleMicrofluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticlesen_US
dc.typePostprinten_US

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