Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed

Simple item page
dc.contributor.authorKo, Junghyuk
dc.contributor.authorMohtaram, Nima Khadem
dc.contributor.authorLee, Patrick C.
dc.contributor.authorWillerth, Stephanie
dc.contributor.authorJun, Martin B.G.
dc.date.accessioned2016-05-24T12:27:29Z
dc.date.available2016-05-24T12:27:29Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.description.abstractMelt electrospinning can be used to fabricate various fibrous biomaterial scaffolds with a range of mechanical properties and varying topographical properties for different applications such as tissue scaffold and filtration and etc., making it a powerful technique. Engineering the topography of such electrospun microfibers can be easily done by tuning the operational parameters of this process. Recent experimental studies have shown promising results for fabricating various topographies, but there is not that body of work that focuses on using mathematical models of this technique to further understand the effect of operational parameters on these properties of microfiber scaffolds. In this study, we developed a novel mathematical model using numerical simulations to demonstrate the effect of temperature, feed rate and flow rate on controlling topographical properties such as fiber diameter of these spun fibrous scaffolds. These promising modelling results are also compared to our previous and current experimental results. Overall, we show that our novel mathematical model can predict the topographical properties affected by key operational parameters such as change in temperature, flow rate and feed rate and this model could serve as a promising strategy for the controlling of topographical properties of such structures for different applications.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipFunding support from Natural Sciences and Engineering Research Council (NSERC) Discovery Grants is acknowledged. The authors would also like to acknowledge the Advanced Microscopy Facility at the University of Victoria.en_US
dc.identifier.citationKo, J., Mohtaram, N.K., Lee, P.C., Willerth, S.M. & Jun, M.B.G. (2015). Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed. Journal of Micromechanics and Microengineering, 25(4), 1-11.en_US
dc.identifier.urihttp://dx.doi.org/10.1088/0960-1317/25/4/045018
dc.identifier.urihttp://hdl.handle.net/1828/7313
dc.language.isoenen_US
dc.publisherJournal of Micromechanics and Microengineeringen_US
dc.subjectMelt electrospinning
dc.subjectModeling
dc.subjectTopography
dc.subjectMicrofibers
dc.subjectScaffolds
dc.subject.departmentDepartment of Mechanical Engineering
dc.subject.departmentSchool of Medical Sciences
dc.titleMathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speeden_US
dc.typePostprinten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ko_Junghyuk_JMicromechMicroeng_2015.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.74 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.