A chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trial

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dc.contributor.authorOviedo-Joekes, Eugenia
dc.contributor.authorMarchand, Kirsten
dc.contributor.authorLock, Kurt
dc.contributor.authorChettiar, Jill
dc.contributor.authorMarsh, David C.
dc.contributor.authorBrissette, Suzanne
dc.contributor.authorAnis, Aslam H
dc.contributor.authorSchechter, Martin T
dc.date.accessioned2015-06-03T23:10:44Z
dc.date.available2015-06-03T23:10:44Z
dc.date.copyright2014en_US
dc.date.issued2014-09-29
dc.descriptionBioMed Centralen_US
dc.description.abstractBackground: The North American Opiate Medication Initiative (NAOMI) clinical trial compared the effectiveness of injectable diacetylmorphine (DAM) or hydromorphone (HDM) to oral methadone maintenance treatment (MMT). This study aimed to determine participants’ perceptions of treatment delivered in NAOMI. Methods: A qualitative sub-study was conducted with 29 participants (12 female): 18 (62.1%) received injectable DAM or HDM and 11 (37.9%) received MMT. A phenomenological theoretical framework was used. Semi-structured interviews were audio-recorded and transcribed verbatim. A thematic analysis was used over successive phases and was driven by the semantic meanings of the data. Results: Participants receiving injectable medications suggested that the supervised delivery model was stringent but provided valuable stability to their lives. Females discussed the adjustment required for the clinical setting, while males focused on the challenging clinic schedule and its impact on employment abilities. Participants receiving MMT described disappointment with being randomized to this treatment; however, positive aspects, including the quick titration time and availability of auxiliary services, were also discussed. Conclusion: Treatment with injectable DAM (or HDM) is preferred by participants and considered effective in reducing the burden of opioid dependency. Engaging patients in research regarding their perceptions of treatment provides a comprehensive assessment of treatment needs and barriers. Clinical trial registration: NCT00175357en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe NAOMI trial was funded through an operating grant from the Canadian Institutes of Health Research with additional support from the Canada Foundation for Innovation, the Canada Research Chairs Program, the University of British Columbia, Providence Health Care, the University of Montreal, Centre de Recherche et Aide aux Narcomanes, the Government of Quebec, Vancouver Coastal Health Authority, and the BC Centre for Disease Control. Dr. Oviedo-Joekes is also funded by the Michael Smith Foundation for Health Research and the Canadian Institutes of Health Research.en_US
dc.identifier.citationOviedo-Joekes et al.: A chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trial. Addiction Science & Clinical Practice 2014 9:21.en_US
dc.identifier.urihttp://www.ascpjournal.org/content/9/1/21
dc.identifier.urihttp://dx.doi.org/10.1186/1940-0640-9-21
dc.identifier.urihttp://hdl.handle.net/1828/6225
dc.language.isoenen_US
dc.publisherAddiction Science & Clinical Practiceen_US
dc.rightsAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectCanadian Institute for Substance Use Research (CISUR)
dc.subjectCentre for Addictions Research of BC (CARBC)
dc.subjectOpioid dependency
dc.subjectDiacetylmorphine
dc.subjectInjectable
dc.subjectOral methadone
dc.subjectOpioid maintenance treatment
dc.subjectQualitative methods
dc.titleA chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trialen_US
dc.typeArticleen_US

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