Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection

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dc.contributor.authorPinto, Carla M.A.
dc.contributor.authorCarvalho, Ana R.M.
dc.contributor.authorBaleanu, Dumitru
dc.contributor.authorSrivastava, Hari M.
dc.date.accessioned2019-07-15T22:22:20Z
dc.date.available2019-07-15T22:22:20Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractWe propose a fractional order model to study the efficacy of the Post-Exposure Prophylaxis (PEP) in human immunodeficiency virus (HIV) within-host dynamics, in the presence of the HIV latent reservoir. Latent reservoirs harbor infected cells that contain a transcriptionally silent but reactivatable provirus. The latter constitutes a major difficulty to the eradication of HIV in infected patients. PEP is used as a way to prevent HIV infection after a recent possible exposure to HIV. It consists of the in-take of antiretroviral drugs for, usually, 28 days. In this study, we focus on the dosage and dosage intervals of antiretroviral therapy (ART) during PEP and in the role of the latent reservoir in HIV infected patients. We thus simulate the model for immunologically important parameters concerning the drugs and the fraction of latently infected cells. The results may add important information to clinical practice of HIV infected patients.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors were partially funded by the European Regional Development Fund through the program COMPETE and by the Portuguese Government through the FCT - Fundação para a Ciência e a Tecnologia under the project PEst-C/MAT/UI0144/2013. The research of AC was partially supported by an FCT grant with reference SFRH/BD/96816/2013.en_US
dc.identifier.citationPinto, C.M.A., Carvalho, A.R.M., Baleanu, D. & Srivastava, H.M. (2019). Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection. Mathematics, 7(6), 515. https://doi.org/10.3390/math7060515en_US
dc.identifier.urihttp://dx.doi.org/10.3390/math7060515
dc.identifier.urihttp://hdl.handle.net/1828/10966
dc.language.isoenen_US
dc.publisherMathematicsen_US
dc.subjectPost-Exposure Prophylaxis
dc.subjectlatent reservoir
dc.subjectHIV infection
dc.subjectfractional order model
dc.subject.departmentDepartment of Mathematics and Statistics
dc.titleEfficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infectionen_US
dc.typeArticleen_US

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