A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force
| dc.contributor.author | Mazerati, Andrey | |
| dc.contributor.author | Jones, Nigel C. | |
| dc.contributor.author | Galanopoulou, Aristea S. | |
| dc.contributor.author | Harte-Hargrove, Lauren C. | |
| dc.contributor.author | Kalynchuk, Lisa E. | |
| dc.contributor.author | Lenck-Santini, Pierre-Pascal | |
| dc.contributor.author | Medel-Matus, Jesus-Servando | |
| dc.contributor.author | Nehlig, Astrid | |
| dc.contributor.author | Prida, Liset Menendez de la | |
| dc.contributor.author | Sarkisova, Karine | |
| dc.contributor.author | Veliskova, Jana | |
| dc.date.accessioned | 2020-08-20T17:19:25Z | |
| dc.date.available | 2020-08-20T17:19:25Z | |
| dc.date.copyright | 2018 | en_US |
| dc.date.issued | 2018 | |
| dc.description.abstract | The provided companion has been developed by the Behavioral Working Group of the Joint Translational Task Force of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) with the purpose of assisting the implementation of Preclinical Common Data Elements (CDE) for studying and for reporting neurobehavioral comorbidities in rodent models of epilepsy. Case Report Forms (CRFs) are provided, which should be completed on a per animal/per test basis, whereas the CDEs are a compiled list of the elements that should be reported. This companion is not designed as a list of recommendations, or guidelines for how the tests should be run—rather, it describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard. The tests are divided into 7 categories for examining behavioral dysfunction on the syndrome level: deficits in learning and memory; depression; anxiety; autism; attention deficit/hyperactivity disorder; psychosis; and aggression. Correspondence and integration of these categories into the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is introduced. Developmental aspects are addressed through the introduction of developmental milestones. Discussion includes complexities, limitations, and biases associated with neurobehavioral testing, especially when performed in animals with epilepsy, as well as the importance of rigorous data collection and of transparent reporting. This represents, to our knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | This report was written by experts selected by the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) and was approved for publication by the ILAE and the AES. Opinions expressed by the authors, however, do not necessarily represent the policy or position of the ILAE or the AES. We are also grateful to the AES, ILAE, and NIH/NINDS for partially sponsoring the activities of the ILAE/AES Joint Translational Task Force. This report is a product of the Behavioral Common Data Element working group of the TASK3 of the ILAE/AES Joint Translational Task Force. We are grateful to the co‐leaders of the TASK3, Drs. Helen Scharfman, Jacqueline French, Asla Pitkänen, and to the NINDS liaison Dr. Vicky Whittemore for their valuable input. AM acknowledges research grant R01NS065783 (NIH/NINDS). ASG acknowledges grant support by NINDS RO1 NS091170, U54 NS100064, the US Department of Defense (W81XWH‐13‐1‐0180), and research funding from the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/ Dan Levitz families. LMP was supported by the grant BFU2015‐66887‐R from the Spanish Ministerio de Economia y Competitividad (MINECO). KS was supported by grant № 13‐04‐01051a from the Russian Foundation for Basic Research (RFBR). | en_US |
| dc.identifier.citation | Mazarati, A., Jones, N. C., Galanopoulou, A. S., Harte-Hargrove, L. C., Kalynchuk, L. E., Lenck-Santini, P., Medel-Matus, J, … & Veliskova, J. (2018). A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force. Epilepsia Open, 3(S1), 24-52. https://doi.org/10.1002/epi4.12236. | en_US |
| dc.identifier.uri | https://doi.org/10.1002/epi4.12236 | |
| dc.identifier.uri | http://hdl.handle.net/1828/12002 | |
| dc.language.iso | en | en_US |
| dc.publisher | Epilepsia Open | en_US |
| dc.subject | Animal models | |
| dc.subject | Behavior | |
| dc.subject | Comorbidities | |
| dc.subject | Epilepsy | |
| dc.subject.department | Division of Medical Sciences | |
| dc.subject.department | School of Medical Sciences | |
| dc.title | A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force | en_US |
| dc.type | Article | en_US |