Microglia as a hub for suicide neuropathology: Future investigation and prevention targets

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dc.contributor.authorGonçalves de Andrade, Elisa
dc.contributor.authorGonzález Ibáñez, Fernando
dc.contributor.authorTremblay, Marie-Ève
dc.date.accessioned2024-02-02T22:11:50Z
dc.date.available2024-02-02T22:11:50Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.descriptionWe are grateful to Benneth Ben-Azu for his careful revision of the manuscript.en_US
dc.description.abstractSuicide is a complex public health challenge associated worldwide with one death every 40 s. Research advances in the neuropathology of suicidal behaviors (SB) have defined discrete brain changes which may hold the key to suicide prevention. Physiological differences in microglia, the resident immune cells of the brain, are present in postmortem tissue samples of individuals who died by suicide. Furthermore, microglia are mechanistically implicated in the outcomes of important risk factors for SB, including early-life adversity, stressful life events, and psychiatric disorders. SB risk factors result in inflammatory and oxidative stress activities which could converge to microglial synaptic remodeling affecting susceptibility or resistance to SB. To push further this perspective, in this Review we summarize current areas of opportunity that could untangle the functional participation of microglia in the context of suicide. Our discussion centers around microglial state diversity in respect to morphology, gene and protein expression, as well as function, depending on various factors, namely brain region, age, and sex.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by Natural Sciences and Engineering Research Council (NSERC), Canadian Institutes of Health Research (CIHR) of Canada, and ERA-NET Neuron, Synaptic Dysfunction in Disorders of the Central Nervous System (MicroSynDep) grants awarded to M-ÈT. EGA was supported by a Graduate Entrance Award from the University of Victoria. FGI was supported by a scholarship from the Mexican Council of Science and Technology (CONACYT). M-ÈT is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition.en_US
dc.identifier.citationGonçalves de Andrade, E., González Ibáñez, F., Tremblay, M-È. (2022). Microglia as a hub for suicide neuropathology: Future investigation and prevention targets. Frontiers in Cellular Neuroscience, 16, 839396. https://doi.org/10.3389/fncel.2022.839396en_US
dc.identifier.urihttps://doi.org/10.3389/fncel.2022.839396
dc.identifier.urihttp://hdl.handle.net/1828/15927
dc.language.isoenen_US
dc.publisherFrontiers in Cellular Neuroscienceen_US
dc.subjectmicrogliaen_US
dc.subjectsuicideen_US
dc.subjectstressen_US
dc.subjectepigeneticsen_US
dc.subjectinflammationen_US
dc.subjectoxidative stressen_US
dc.subjectneuronal supporten_US
dc.subjectsynaptic plasticityen_US
dc.titleMicroglia as a hub for suicide neuropathology: Future investigation and prevention targetsen_US
dc.typeArticleen_US

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