Does chronic stress alter reelin in the entorhinal cortex?

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dc.contributor.authorKurz, Katerina
dc.date.accessioned2024-03-15T15:58:05Z
dc.date.available2024-03-15T15:58:05Z
dc.date.issued2024
dc.description.abstractChronic stress (CS) is a risk factor for depression and Alzheimer’s disease (AD). The entorhinal cortex (EC) is the region first showing deterioration in AD. Reelin, which regulates synaptic plasticity, is dysregulated in the hippocampus following CS, in depression and AD, and in the EC following age-related cognitive decline. To examine the effect of CS on reelin+ cells in the EC, 36 rats underwent a cyclic CS model of recurring depression. A subset of rats received an injection of reelin on the last day to determine whether reelin treatment reverses depression-like behaviour and restores reelin in the EC. Reelin treatment reversed depression-like behaviour, but no effect of CS on EC reelin+ cell density was observed, suggesting that CS does not affect EC reelin as it does in other regions. Correlations were examined between reelin+ cell density, forced swim test immobility, and spatial memory. There was no relationship between reelin+ cell density and immobility time, however there was a significant correlation between spatial memory and reelin cell density in males. This correlation was disrupted with chronic stress but successfully recovered with a reelin injection, suggesting a relationship between spatial memory and reelin levels in the EC.
dc.description.reviewstatusReviewed
dc.description.scholarlevelUndergraduate
dc.description.sponsorshipJamie Cassels Undergraduate Research Awards (JCURA)
dc.identifier.urihttps://hdl.handle.net/1828/16107
dc.language.isoen
dc.publisherUniversity of Victoria
dc.subjectChronic stress
dc.subjectentorhinal cortex
dc.subjectreelin
dc.subjectdepression
dc.subjectspatial memory
dc.subjectrodent
dc.titleDoes chronic stress alter reelin in the entorhinal cortex?
dc.typePoster

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