Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease

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dc.contributor.authorVecchiarelli, Haley A.
dc.contributor.authorTremblay, Marie-Ève
dc.date.accessioned2024-01-25T22:54:03Z
dc.date.available2024-01-25T22:54:03Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.descriptionWe acknowledge with respect the Lekwungen peoples on whose traditional territory the University of Victoria stands, and the Songhees, Esquimalt and WSÁNEĆ peoples whose historical relationships with the land continue to this day. We acknowledge the following Tremblay laboratory members for their thoughtful review of the manuscript: Adriano José Maia Chaves Filho, Chloe McKee, Colin Murray, Katherine Picard, and Eva Šimončičová. We apologize to the many researchers whose work could not be appropriately cited due to space constraints.en_US
dc.description.abstractMicroglia, the resident immune cells of the central nervous system (CNS), are primarily derived from the embryonic yolk sac and make their way to the CNS during early development. They play key physiological and immunological roles across the life span, throughout health, injury, and disease. Recent transcriptomic studies have identified gene transcript signatures expressed by microglia that may provide the foundation for unprecedented insights into their functions. Microglial gene expression signatures can help distinguish them from macrophage cell types to a reasonable degree of certainty, depending on the context. Microglial expression patterns further suggest a heterogeneous population comprised of many states that vary according to the spatiotemporal context. Microglial diversity is most pronounced during development, when extensive CNS remodeling takes place, and following disease or injury. A next step of importance for the field will be to identify the functional roles performed by these various microglial states, with the perspective of targeting them therapeutically.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipH.A.V. is supported by a fellowship from the Canadian Institutes of Health Research and is a Michael Smith Health Research BC Research Trainee. M.-È.T. holds a Canada Research Chair (Tier 2) in Neurobiology of Aging and Cognition.en_US
dc.identifier.citationVecchiarelli, H. A., & Tremblay, M-È. (2023). Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease. Annual Review of Genetics, 57, 65-86. https://doi.org/10.1146/annurev-genet-022223-093643en_US
dc.identifier.urihttps://doi.org/10.1146/annurev-genet-022223-093643
dc.identifier.urihttp://hdl.handle.net/1828/15895
dc.language.isoenen_US
dc.publisherAnnual Review of Geneticsen_US
dc.subjectmicroglia
dc.subjectmicroglial heterogeneity
dc.subjectRNA sequencing
dc.subjecttranscriptomic signatures
dc.subjectcentral nervous system
dc.subjectCenter for Advanced Materials and Related Technology (CAMTEC)
dc.subjectInstitute on Aging and Lifelong Health
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleMicroglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and diseaseen_US
dc.typeArticleen_US

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We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.