Microfluidic-based oxygen (O2) sensors for on-chip monitoring of cell, tissue and organ metabolism

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dc.contributor.authorAzimzadeh, Mostafa
dc.contributor.authorKhashayar, Patricia
dc.contributor.authorAmereh, Meitham
dc.contributor.authorTasnim, Nishat
dc.contributor.authorHoorfar, Mina
dc.contributor.authorAkbari, Mohsen
dc.date.accessioned2022-11-19T16:08:09Z
dc.date.available2022-11-19T16:08:09Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractOxygen (O₂) quantification is essential for assessing cell metabolism, and its consumption in cell culture is an important indicator of cell viability. Recent advances in microfluidics have made O₂ sensing a crucial feature for organ-on-chip (OOC) devices for various biomedical applications. OOC O₂ sensors can be categorized, based on their transducer type, into two main groups, optical and electrochemical. In this review, we provide an overview of on-chip O₂ sensors integrated with the OOC devices and evaluate their advantages and disadvantages. Recent innovations in optical O₂ sensors integrated with OOCs are discussed in four main categories: (i) basic luminescence-based sensors; (ii) microparticle-based sensors; (iii) nano-enabled sensors; and (iv) commercial probes and portable devices. Furthermore, we discuss recent advancements in electrochemical sensors in five main categories: (i) novel configurations in Clark-type sensors; (ii) novel materials (e.g., polymers, O₂ scavenging and passivation materials); (iii) nano-enabled electrochemical sensors; (iv) novel designs and fabrication techniques; and (v) commercial and portable electrochemical readouts. Together, this review provides a comprehensive overview of the current advances in the design, fabrication and application of optical and electrochemical O₂ sensors.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipWe would like to acknowledge the support received by the National Sciences and Engineering Research Council of Canada (NSERC).en_US
dc.identifier.citationAzimzadeh, M., Khashavar, P., Amereh, M., Tasnim, N., Hoorfar, M., & Akbari, M. (2021). “Microfluidic-based oxygen (O2) sensors for on-chip monitoring of cell, tissue and organ metabolism.” Biosensors, 12(1), 6. https://doi.org/10.3390/bios12010006en_US
dc.identifier.urihttps://doi.org/10.3390/bios12010006
dc.identifier.urihttp://hdl.handle.net/1828/14507
dc.language.isoenen_US
dc.publisherBiosensorsen_US
dc.subjectoxygen sensorsen_US
dc.subjectmicrofluidicsen_US
dc.subjectorgan-on-chips (OOCs)en_US
dc.subjecton-chip monitoringen_US
dc.subjectLaboratory for Innovations in Micro Engineering (LiME)
dc.subjectCAMTEC
dc.titleMicrofluidic-based oxygen (O2) sensors for on-chip monitoring of cell, tissue and organ metabolismen_US
dc.typeArticleen_US

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