Does early life exposure to exogenous sources of reactive oxygen species (ROS) increase the risk of respiratory and allergic diseases in children? A longitudinal cohort study

dc.contributor.authorTo, Teresa
dc.contributor.authorTerebessy, Emilie
dc.contributor.authorZhu, Jingqin
dc.contributor.authorZhang, Kimball
dc.contributor.authorLakey, Pascale SJ
dc.contributor.authorShiraiwa, Manabu
dc.contributor.authorHatzopoulou, Marianne
dc.contributor.authorMinet, Laura
dc.contributor.authorWeichenthal, Scott
dc.contributor.authorDell, Sharon
dc.contributor.authorStieb, Dave
dc.date.accessioned2023-01-10T23:50:07Z
dc.date.available2023-01-10T23:50:07Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.description.abstractBackground Excess reactive oxygen species (ROS) can cause oxidative stress damaging cells and tissues, leading to adverse health effects in the respiratory tract. Yet, few human epidemiological studies have quantified the adverse effect of early life exposure to ROS on child health. Thus, this study aimed to examine the association of levels of ROS exposure at birth and the subsequent risk of developing common respiratory and allergic diseases in children. Methods 1,284 Toronto Child Health Evaluation Questionnaire (T-CHEQ) participants were followed from birth (born between 1996 and 2000) until outcome, March 31, 2016 or loss-to-follow-up. Using ROS data from air monitoring campaigns and land use data in Toronto, ROS concentrations generated in the human respiratory tract in response to inhaled pollutants were estimated using a kinetic multi-layer model. These ROS values were assigned to participants’ postal codes at birth. Cox proportional hazards regression models, adjusted for confounders, were then used to estimate hazard ratios (HR) with 95% confidence intervals (CI) per unit increase in interquartile range (IQR). Results After adjusting for confounders, iron (Fe) and copper (Cu) were not significantly associated with the risk of asthma, allergic rhinitis, nor eczema. However, ROS, a measure of the combined impacts of Fe and Cu in PM2.5, was associated with an increased risk of asthma (HR = 1.11, 95% CI: 1.02–1.21, p < 0.02) per IQR. There were no statistically significant associations of ROS with allergic rhinitis (HR = 0.96, 95% CI: 0.88–1.04, p = 0.35) and eczema (HR = 1.03, 95% CI: 0.98–1.09, p = 0.24). Conclusion These findings showed that ROS exposure in early life significantly increased the childhood risk of asthma, but not allergic rhinitis and eczema.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis study was funded by Health Canada, Contract No. HT421-163216/001/SS. Health Canada had a role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.en_US
dc.identifier.citationTo, T., Terebessy, E., Zhu, J., Zhang, K., Lakey, P. S. J., Shiraiwa, M., . . . Stieb, D. (2022). “Does early life exposure to exogenous sources of reactive oxygen species (ROS) increase the risk of respiratory and allergenic diseases in children? A longitudinal cohort study.” Environmental Health, 21(90). https://doi.org/10.1186/s12940-022-00902-7en_US
dc.identifier.urihttps://doi.org/10.1186/s12940-022-00902-7
dc.identifier.urihttp://hdl.handle.net/1828/14647
dc.language.isoenen_US
dc.publisherEnvironmental Healthen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectAsthmaen_US
dc.subjectAllergic rhinitisen_US
dc.subjectEczemaen_US
dc.subjectAir pollutionen_US
dc.subjectEarly life exposuresen_US
dc.titleDoes early life exposure to exogenous sources of reactive oxygen species (ROS) increase the risk of respiratory and allergic diseases in children? A longitudinal cohort studyen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Minet_Laura_EnvironHealth_2022.pdf
Size:
983.81 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description: