Concurrent Indicators of Gait Velocity and Variability Are Associated with 25-Year Cognitive Change: A Retrospective Longitudinal Investigation

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dc.contributor.authorMacDonald, Stuart W.S.
dc.contributor.authorHundza, Sandra
dc.contributor.authorLove, Janet A.
dc.contributor.authorDeCarlo, Correne A.
dc.contributor.authorHalliday, Drew W. R.
dc.contributor.authorBrewster, Paul W. H.
dc.contributor.authorLukyn, Timothy V.
dc.contributor.authorCamicioli, Richard
dc.contributor.authorDixon, Roger A.
dc.date.accessioned2018-08-02T17:50:09Z
dc.date.available2018-08-02T17:50:09Z
dc.date.copyright2017en_US
dc.date.issued2017-02
dc.description.abstractBackground/Objectives: Physical function indicators, including gait velocity, stride time and step length, are linked to neural and cognitive function, morbidity and mortality. Whereas cross-sectional associations are well documented, far less is known about long-term patterns of cognitive change as related to objective indicators of mobility-related physical function. Methods: Using data from the Victoria Longitudinal Study, a long-term investigation of biological and health aspects of aging and cognition, we examined three aspects of cognition-physical function linkages in 121 older adults. First, we examined a simple marker of physical function (3 m timed-walk) as a predictor of cross-sectional differences and up to 25-year change for four indicators of cognitive function. Second, we tested associations between two markers of gait function derived from the GAITRite system (velocity and stride-time variability) and differences and change in cognition. Finally, we evaluated how increasing cognitive load during GAITRite assessment influenced the associations between gait and cognition. Results: The simple timed-walk measure, commonly used in clinical and research settings, was a minor predictor of change in cognitive function. In contrast, the objectively measured indicator of walking speed significantly moderated long-term cognitive change. Under increasing cognitive load, the moderating influence of velocity on cognitive change increased, with increasing variability in stride time also emerging as a predictor of age-related cognitive decline. Conclusion: These findings: (a) underscore the utility of gait as a proxy for biological vitality and for indexing long-term cognitive change; and (b) inform potential mechanisms underlying age-related linkages in physical and cognitive function.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by a grant from the National Institutes of Health/National Institute on Aging (R01 AG008235) to RAD, who also acknowledges support from the Canada Research Chairs program. SWSM was supported by grants from the National Institutes of Health/National Institute on Aging (R21 AG045575) and the Natural Sciences and Engineering Research Council of Canada (418676-2012).en_US
dc.identifier.citationMacDonald, S.W.S.; Hundza, S.; Love, J.A.; DeCarlo, C.A.; Halliday, D.W.R.; Brester, P.W.H.; … & Dixon, R.A. (2017). Concurrent indicators of gait velocity and variability are associated with 25-year cognitive change: A retrospective longitudinal investigation. Frontiers in Aging Neuroscience, 9, article 17. https://doi.org/10.3389/fnagi.2017.00017en_US
dc.identifier.urihttps://doi.org/10.3389/fnagi.2017.00017
dc.identifier.urihttp://hdl.handle.net/1828/9818
dc.language.isoenen_US
dc.publisherFrontiers in Aging Neuroscienceen_US
dc.subjectcognitive changeen_US
dc.subjectphysical functionen_US
dc.subjectgaiten_US
dc.subjectvariabilityen_US
dc.subjectVictoria Longitudinal Studyen_US
dc.titleConcurrent Indicators of Gait Velocity and Variability Are Associated with 25-Year Cognitive Change: A Retrospective Longitudinal Investigationen_US
dc.typeArticleen_US

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