Molecular basis underlying the therapeutic potential of vitamin D for the treatment of depression and anxiety

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dc.contributor.authorKouba, Bruna R.
dc.contributor.authorCamargo, Anderson
dc.contributor.authorGil-Mohapel, Joana
dc.contributor.authorRodrigues, Ana LĂșcia S.
dc.date.accessioned2022-11-12T18:23:21Z
dc.date.available2022-11-12T18:23:21Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.description.abstractMajor depressive disorder and anxiety disorders are common and disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms of depression and anxiety frequently overlap in individuals, making them difficult to diagnose and treat adequately. Therefore, compounds capable of exerting beneficial effects against both disorders are of special interest. Noteworthily, vitamin D deficiency has been associated with an increased risk of developing depression and anxiety, and individuals with these psychiatric conditions have low serum levels of this vitamin. Indeed, in the last few years, vitamin D has gained attention for its many functions that go beyond its effects on calcium–phosphorus metabolism. Particularly, antioxidant, anti-inflammatory, pro-neurogenic, and neuromodulatory properties seem to contribute to its antidepressant and anxiolytic effects. Therefore, in this review, we highlight the main mechanisms that may underlie the potential antidepressant and anxiolytic effects of vitamin D. In addition, we discuss preclinical and clinical studies that support the therapeutic potential of this vitamin for the management of these disorders.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; #421143/2018-5 and #312215/2021-5) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). J.G.M. acknowledges funding from the University of Victoria (UVic, Victoria, BC, Canada)—São Paulo Research Foundation (FAPESP, São Paulo, SP, Brazil) SPRINT partnership (UVic-FAPESP SPRINT 1/2018 Grant). A.L.S.R. is CNPq Research Fellow.en_US
dc.identifier.citationKouba, B., Camargo, A., Gil-Mohapel, J., & Rodrigues, A. (2022). “Molecular basis underlying the therapeutic potential of vitamin D for the treatment of depression and anxiety.” International Journal of Molecular Sciences, 23(13), 7077. https://doi.org/10.3390/ijms23137077en_US
dc.identifier.urihttps://doi.org/10.3390/ijms23137077
dc.identifier.urihttp://hdl.handle.net/1828/14447
dc.language.isoenen_US
dc.publisherInternational Journal of Molecular Sciencesen_US
dc.subjectanti-inflammatory effect
dc.subjectanxiety
dc.subjectdepression
dc.subjectneuromodulator
dc.subjectpro-neurogenic effect
dc.subjectvitamin D
dc.subjectIsland Medical Program
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleMolecular basis underlying the therapeutic potential of vitamin D for the treatment of depression and anxietyen_US
dc.typeArticleen_US

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