Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation

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dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorGholami, Mohammad Hossein
dc.contributor.authorMahabady, Mahmood Khaksary
dc.contributor.authorNabavi, Noushin
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorBanihashemi, Seyed Mohammad
dc.contributor.authorHaddadi, Amirabbas
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorMakvandi, Pooyan
dc.contributor.authorSamarghandian, Saeed
dc.contributor.authorZarrabi, Ali
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorKhan, Haroon
dc.date.accessioned2021-03-01T23:09:43Z
dc.date.available2021-03-01T23:09:43Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractEffective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation and invasion of cancer cells. Among molecular pathways, signal transducer and activator of transcription 3 (STAT3) has been of importance due to its involvement in promoting proliferation, and invasion of cancer cells, and mediating chemoresistance. In the present review, our aim is to reveal role of STAT3 pathway in bladder cancer (BC), as one of the leading causes of death worldwide. In respect to its tumor-promoting role, STAT3 is able to enhance the growth of BC cells via inhibiting apoptosis and cell cycle arrest. STAT3 also contributes to metastasis of BC cells via upregulating of MMP-2 and MMP-9 as well as genes in the EMT pathway. BC cells obtain chemoresistance via STAT3 overexpression and its inhibition paves the way for increasing efficacy of chemotherapy. Different molecular pathways such as KMT1A, EZH2, DAB2IP and non-coding RNAs including microRNAs and long non-coding RNAs can function as upstream mediators of STAT3 that are discussed in this review article.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationMirzaei, S., Gholami, M. H., Mahabady, M. K., Nabavi, N., Zabolian, A., Bamihashemi, S. M., … Khan, H. (2021). Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation. Biomedicine & Pharmacotheraphy, 133, 1-12. https://doi.org/10.1016/j.biopha.2020.111077.en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2020.111077
dc.identifier.urihttp://hdl.handle.net/1828/12725
dc.language.isoenen_US
dc.publisherBiomedicine & Pharmacotherapyen_US
dc.subjectSignal transducer and activator of transcription
dc.subject3 (STAT3)
dc.subjectBladder cancer
dc.subjectMicroRNA
dc.subjectLncRNA
dc.subjectMetastasis
dc.subjectChemoresistance
dc.titlePre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translationen_US
dc.typeArticleen_US

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