The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA
| dc.contributor.author | Hammond, S. Austin | |
| dc.contributor.author | Warren, Rene L. | |
| dc.contributor.author | Vandervalk, Benjamin P. | |
| dc.contributor.author | Kucuk, Erdi | |
| dc.contributor.author | Khan, Hamza | |
| dc.contributor.author | Gibb, Ewan A. | |
| dc.contributor.author | Pandoh, Pawan | |
| dc.contributor.author | Kirk, Heather | |
| dc.contributor.author | Zhao, Yongjun | |
| dc.contributor.author | Jones, Martin | |
| dc.contributor.author | Mungall, Andrew J. | |
| dc.contributor.author | Coope, Robin | |
| dc.contributor.author | Pleasance, Stephen | |
| dc.contributor.author | Moore, Richard A. | |
| dc.contributor.author | Holt, Robert A. | |
| dc.contributor.author | Round, Jessica M. | |
| dc.contributor.author | Ohora, Sara | |
| dc.contributor.author | Walle, Branden V. | |
| dc.contributor.author | Veldhoen, Nik | |
| dc.contributor.author | Helbing, Caren C. | |
| dc.contributor.author | Birol, Inanc | |
| dc.date.accessioned | 2019-02-06T15:45:38Z | |
| dc.date.available | 2019-02-06T15:45:38Z | |
| dc.date.copyright | 2017 | en_US |
| dc.date.issued | 2017 | |
| dc.description.abstract | Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines. We report a 5.8 Gbp (NG50 = 69 kbp) genome assembly of a representative North American bullfrog (Rana [Lithobates] catesbeiana). The genome contains over 22,000 predicted protein-coding genes and 6,223 candidate long noncoding RNAs (lncRNAs). RNA-Seq experiments show thyroid hormone causes widespread transcriptional change among protein-coding and putative lncRNA genes. This initial bullfrog draft genome will serve as a key resource with broad utility including amphibian research, developmental biology, and environmental research. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | This work has been supported by Genome British Columbia and Natural Sciences and Engineering Research Council of Canada, with additional support provided by the National Human Genome Research Institute of the National Institutes of Health (under award number R01HG007182). The content is solely the responsibility of the authors, and does not necessarily represent the official views of the National Institutes of Health or other funding organizations. We thank Dr. Belaid Moa for advanced research computing support from WestGrid, Compute Canada, and the University of Victoria computing systems. | en_US |
| dc.identifier.citation | Hammond, S. A.; Warren, R. L.; Vandervalk, B. P.; Kucuk, E.; Khan, H.; Gibb, E. W.; … & Birol, I. (2017). The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA. Nature Communications, 8(1433). DOI: 10.1038/s41467-017-01316-7 | en_US |
| dc.identifier.uri | https://doi.org/10.1038/s41467-017-01316-7 | |
| dc.identifier.uri | http://hdl.handle.net/1828/10590 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nature Communications | en_US |
| dc.subject.department | Department of Microbiology and Biochemistry | |
| dc.subject.department | Department of Biochemistry and Microbiology | |
| dc.title | The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA | en_US |
| dc.type | Article | en_US |