Synthesis of gelatin methacryloyl analogs and their use in the fabrication of pH-responsive microspheres

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dc.contributor.authorValente, Karolina
dc.contributor.authorBoice, Genevieve Nicole
dc.contributor.authorPolglase, Cameron
dc.contributor.authorBelli, Roman
dc.contributor.authorBourque, Elaina
dc.contributor.authorSuleman, Afzal
dc.contributor.authorBrolo, Alexandre G.
dc.date.accessioned2024-09-23T21:57:14Z
dc.date.available2024-09-23T21:57:14Z
dc.date.copyright2024
dc.date.issued2024
dc.description.abstractpH-responsive hydrogels have numerous applications in tissue engineering, drug delivery systems, and diagnostics. Gelatin methacryloyl (GelMA) is a biocompatible, semi-synthetic polymer prepared from gelatin. When combined with aqueous solvents, GelMA forms hydrogels that have extensive applications in biomedical engineering. GelMA can be produced with different degrees of methacryloyl substitution; however, the synthesis of this polymer has not been tuned towards producing selectively modified materials for single-component pH-responsive hydrogels. In this work, we have explored two different synthetic routes targeting different gelatin functional groups (amine, hydroxyl, and/or carboxyl) to produce two GelMA analogs: gelatin A methacryloyl glycerylester (polymer A) and gelatin B methacrylamide (polymer B). Polymers A and B were used to fabricate pH-responsive hydrogel microspheres in a flow-focusing microfluidic device. At neutral pH, polymer A and B microspheres displayed an average diameter of ~40 µm. At pH 6, microspheres from polymer A showed a swelling ratio of 159.1 ± 11.5%, while at pH 10, a 288.6 ± 11.6% swelling ratio was recorded for polymer B particles.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.identifier.citationValente, K., Boice, G. N., Polglase, C., Belli, R. G., Bourque, E., Suleman, A., & Brolo, A. (2024). Synthesis of gelatin methacryloyl analogs and their use in the fabrication of PH-Responsive microspheres. Pharmaceutics, 16(8), 1016. https://doi.org/10.3390/pharmaceutics16081016
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics16081016
dc.identifier.urihttps://hdl.handle.net/1828/20449
dc.language.isoen
dc.publisherPharmaceutics
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectpH-responsive hydrogel
dc.subjectgelatin methacryloyl
dc.subjecthydrogel microspheres
dc.subjectflow-focusing microfluidic device
dc.subjectdrug delivery systems
dc.subjectCentre for Advanced Materials and Related Technology (CAMTEC)
dc.subject.departmentDepartment of Mechanical Engineering
dc.subject.departmentDepartment of Chemistry
dc.titleSynthesis of gelatin methacryloyl analogs and their use in the fabrication of pH-responsive microspheres
dc.typeArticle

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