Application of high-Z nanoparticles to enhance current radiotherapy treatment

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dc.contributor.authorJackson, Nolan
dc.contributor.authorCecchi, Daniel
dc.contributor.authorBeckham, Wayne
dc.contributor.authorChithrani, Devika B.
dc.date.accessioned2024-10-10T17:23:09Z
dc.date.available2024-10-10T17:23:09Z
dc.date.issued2024
dc.description.abstractRadiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, the dose escalation required to enhance tumor control is limited due to the inevitable toxicity to the surrounding healthy tissue. Therefore, the local enhancement of dosing in tumor sites can provide the necessary means to improve the treatment modality. In recent years, the emergence of nanotechnology has facilitated a unique opportunity to increase the efficacy of radiotherapy treatment. The application of high-atomic-number (Z) nanoparticles (NPs) can augment the effects of radiotherapy by increasing the sensitivity of cells to radiation. High-Z NPs can inherently act as radiosensitizers as well as serve as targeted delivery vehicles for radiosensitizing agents. In this work, the therapeutic benefits of high-Z NPs as radiosensitizers, such as their tumor-targeting capabilities and their mechanisms of sensitization, are discussed. Preclinical data supporting their application in radiotherapy treatment as well as the status of their clinical translation will be presented.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.description.sponsorshipThis research was funded by a Nanomedicines Innovation Network (NMIN) Strategic Initiative (SI) grant, 2021-RES-SI-05; Natural Sciences and Engineering Research Council (NSERC) Discovery Grant (DG), RGPIN-2017-04501; and Canadian Institute for Health Research (CIHR), CIHR PJT-399879.
dc.identifier.citationJackson, N., Cecchi, D., Beckham, W., & Chithrani, D. B. (2024). Application of high-Z nanoparticles to enhance current radiotherapy treatment. Molecules, 29(11), Article 11. https://doi.org/10.3390/molecules29112438
dc.identifier.urihttps://doi.org/10.3390/molecules29112438
dc.identifier.urihttps://hdl.handle.net/1828/20530
dc.language.isoen
dc.publisherMolecules
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcancer
dc.subjectchemotherapy
dc.subjectnanoparticle
dc.subjectradiosensitizer
dc.subjectradiotherapy
dc.subjecttherapeutics
dc.titleApplication of high-Z nanoparticles to enhance current radiotherapy treatment
dc.typeArticle

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