Impact of negative emotion on the neural correlates of long-term recognition in younger and older adults

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dc.contributor.authorKalpouzsos, G.
dc.contributor.authorFischer, H.
dc.contributor.authorRieckmann, A.
dc.contributor.authorBackman, L.
dc.contributor.authorMacDonald, Stuart W.S.
dc.date.accessioned2021-08-20T23:10:57Z
dc.date.available2021-08-20T23:10:57Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.description.abstractSome studies have suggested that the memory advantage for negative emotional information over neutral information (“negativity effect”) is reduced in aging. Besides the fact that most findings are based on immediate retrieval, the neural underpinnings of long-term emotional memory in aging have so far not been investigated.To address these issues, we assessed recognition of neutral and negative scenes after 1- and 3-week retention intervals in younger and older adults using functional magnetic resonance imaging. We further used an event-related design in order to disentangle successful, false, and true recognition. This study revealed four key findings: (1) increased retention interval induced an increased rate of false recognitions for negative scenes, canceling out the negativity effect (present for hit rates only) on discrimination in both younger and older adults; (2) in younger, but not older, adults, reduced activity of the medial temporal lobe was observed over time for neutral scenes, but not for negative scenes, where stable or increased activity was seen; (3) engagement of amygdala (AMG) was observed in older adults after a 3-week delay during successful recognition of negative scenes (hits vs. misses) in comparison with neutral scenes, which may indicate engagement of automatic processes, but engagement of ventrolateral prefrontal cortex was unrelated to AMG activity and performance; and (4) after 3 weeks, but not after 1 week, true recognition of negative scenes was characterized by more activity in left hippocampus and lateral occipito-temporal regions (hits vs. false alarms). As these regions are known to be related to consolidation mechanisms, the observed pattern may indicate the presence of delayed consolidation of true memories. Nonetheless, older adults’ low performance in discrimination of negative scenes could reflect the fact that overall, after long delays of retention, they rely more on general information rather than on perceptual detail in making recognition judgments.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was funded by grants from the Swedish Research Council and The Bank of Sweden Tercentenary Foundation to Haken Fischer. Lars Backman was supported by grants from the Swedish Research Council, Swedish Brain Power, an Alexander von Humboldt Research award, and a donation from the af Jochnick Foundation. Stuart MacDonald was supported by a Career Scholar Award from the Michael Smith Foundation for Health Research. We thank Joachim Gavazzeni, Floortje Smeets, and Alireza Salami for their contribution to the study.en_US
dc.identifier.citationKalpouzsos, G., Fischer, H., Rieckmann, A., MacDonald, S.W.S., & Backman, L. (2012). Impact of negative emotion on the neural correlates of long-term recognition in younger and older adults. Frontiers in Integrative Neuroscience, 6(74). https://doi.org/10.3389/fnint.2012.00074en_US
dc.identifier.urihttps://doi.org/10.3389/fnint.2012.00074
dc.identifier.urihttp://hdl.handle.net/1828/13296
dc.language.isoenen_US
dc.publisherFrontiers in Integrative Neuroscienceen_US
dc.subjectaging
dc.subjectamygdala
dc.subjectemotion
dc.subjectepisodic memory
dc.subjecthippocampus
dc.subjectlong-term memory
dc.subjectprefrontal cortex
dc.subjectrecognition
dc.subject.departmentDepartment of Psychology
dc.titleImpact of negative emotion on the neural correlates of long-term recognition in younger and older adultsen_US
dc.typeArticleen_US

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