3D printed hydrogel microneedle arrays for interstitial fluid biomarker extraction and colorimetric detection

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dc.contributor.authorRazzaghi, Mahmood
dc.contributor.authorSeyfoori, Amir
dc.contributor.authorPagan, Erik
dc.contributor.authorAskari, Esfandyar
dc.contributor.authorNajafabadi, Alireza Hassani
dc.contributor.authorAkbari, Mohsen
dc.date.accessioned2024-02-06T20:00:52Z
dc.date.available2024-02-06T20:00:52Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.description.abstractTo treat and manage chronic diseases, it is necessary to continuously monitor relevant biomarkers and modify treatment as the disease state changes. Compared to other bodily fluids, interstitial skin fluid (ISF) is a good choice for identifying biomarkers because it has a molecular composition most similar to blood plasma. Herein, a microneedle array (MNA) is presented to extract ISF painlessly and bloodlessly. The MNA is made of crosslinked poly(ethylene glycol) diacrylate (PEGDA), and an optimal balance of mechanical properties and absorption capability is suggested. Besides, the effect of needles’ cross-section shape on skin penetration is studied. The MNA is integrated with a multiplexed sensor that provides a color change in a biomarker concentration-dependent manner based on the relevant reactions for colorimetric detection of pH and glucose biomarkers. The developed device enables diagnosis by visual inspection or quantitative red, green, and blue (RGB) analysis. The outcomes of this study show that MNA can successfully identify biomarkers in interstitial skin fluid in a matter of minutes. The home-based long-term monitoring and management of metabolic diseases will benefit from such practical and self-administrable biomarker detection.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), International Collaboration on Repair Discoveries (ICORD), the Canadian Institutes for Health Research (CIHR), and the Canadian Foundation for Innovation (CFI).en_US
dc.identifier.citationRazzaghi, M., Seyfoori, A., Pagan, E., Askari, E., Hassani Najafabadi, A., & Akbari, M. (2023). 3D printed hydrogel microneedle arrays for interstitial fluid biomarker extraction and colorimetric detection. Polymers, 15(6), 1389. https://doi.org/10.3390/polym15061389en_US
dc.identifier.urihttps://doi.org/10.3390/polym15061389
dc.identifier.urihttp://hdl.handle.net/1828/15951
dc.language.isoenen_US
dc.publisherPolymersen_US
dc.subjectmicroneedle
dc.subjectmicroneedle array
dc.subject3D printing
dc.subjecthydrogel
dc.subjectinterstitial fluid
dc.subjectbiomarker
dc.subjectdetection
dc.subjectLaboratory for Innovations in Micro Engineering (LiME)
dc.subject.departmentDepartment of Mechanical Engineering
dc.title3D printed hydrogel microneedle arrays for interstitial fluid biomarker extraction and colorimetric detectionen_US
dc.typeArticleen_US

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