Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival

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dc.contributor.authorHughson, Luke R.K.
dc.contributor.authorPoon, Vincent I.
dc.contributor.authorSpowart, Jaeline E.
dc.contributor.authorLum, Julian J.
dc.date.accessioned2017-10-19T17:52:15Z
dc.date.available2017-10-19T17:52:15Z
dc.date.copyright2012en_US
dc.date.issued2012-01
dc.description.abstractAccumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective forms of autophagy. These selective forms of autophagy, including mitophagy, nucleophagy, and ubiquitin-mediated autophagy, counteract apoptotic signals by removing damaged cellular structures and by reprogramming cellular energy metabolism to cope with therapeutic stress. As a result, the efficacies of numerous current cancer therapies may be improved by combining them with adjuvant treatments that exploit or disrupt key metabolic processes induced by selective forms of autophagy. Targeting these metabolic irregularities represents a promising approach to improve clinical responsiveness to cancer treatments given the inherently elevated metabolic demands of many tumor types. To what extent anticancer treatments promote selective forms of autophagy and the degree to which they influence metabolism are currently under intense scrutiny. Understanding how the activation of selective forms of autophagy influences cellular metabolism and survival provides an opportunity to target metabolic irregularities induced by these pathways as a means of augmenting current approaches for treating cancer.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThey also wish to acknowledge support from the CIHR New Investigator Award (JJL), CIHR Operating Grant (JJL), CIHR Emerging Team Grant (JJL), British Columbia Cancer Foundation Studentship Award (VIP), Frederick Banting and Charles Best Canada Graduate Scholarship: Masters Award (JES), Ovarian Cancer Canada Teal Heart Scholarship (JES), University of Victoria Graduate Fellowship (JES), and University of Victoria Graduate Award (JES).en_US
dc.identifier.citationHughson, L.R.K., Poon, V.I., Spowart, J.E. & Lum, J.J. (2012). Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival. International Journal of Cell Biology, 2012, 11 pages. http://dx.doi.org/10.1155/2012/872091en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2012/872091
dc.identifier.urihttp://hdl.handle.net/1828/8692
dc.language.isoenen_US
dc.publisherInternational Journal of Cell Biologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleImplications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survivalen_US
dc.typeArticleen_US

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