Microglial contribution to the pathology of neurodevelopmental disorders in humans

Simple item page
dc.contributor.authorMatuleviciute, Rugile
dc.contributor.authorAkinluyi, Elizabeth T.
dc.contributor.authorMuntslag, Tim A. O.
dc.contributor.authorDewing, Jennifer M.
dc.contributor.authorLong, Katherine R.
dc.contributor.authorVernon, Anthony C.
dc.contributor.authorTremblay, Marie-Ève
dc.contributor.authorMenassa, David A.
dc.date.accessioned2024-01-08T22:33:55Z
dc.date.available2024-01-08T22:33:55Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.description.abstractMicroglia are the brain’s resident macrophages, which guide various developmental processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the telencephalic wall by the 4th postconceptional week and colonise the fetal brain in a manner that spatiotemporally tracks key neurodevelopmental processes in humans. However, much of what we know about how microglia shape neurodevelopment comes from rodent studies. Multiple differences exist between human and rodent microglia warranting further focus on the human condition, particularly as microglia are emerging as critically involved in the pathological signature of various cognitive and neurodevelopmental disorders. In this article, we review the evidence supporting microglial involvement in basic neurodevelopmental processes by focusing on the human species. We next concur on the neuropathological evidence demonstrating whether and how microglia contribute to the aetiology of two neurodevelopmental disorders: autism spectrum conditions and schizophrenia. Next, we highlight how recent technologies have revolutionised our understanding of microglial biology with a focus on how these tools can help us elucidate at unprecedented resolution the links between microglia and neurodevelopmental disorders. We conclude by reviewing which current treatment approaches have shown most promise towards targeting microglia in neurodevelopmental disorders and suggest novel avenues for future consideration.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipRM is in receipt of the MRC-Sackler PhD programme studentship as part of the MRC Centre for Neurodevelopmental Disorders (Medical Research Council MR/P502108/1). EA was a recipient of the International Society for Neurochemistry (ISN) Committee for Aid and Education in Neurochemistry (CAEN) 1A grant, and The Company of Biologists Travelling Fellowship (2021). KL acknowledges the Medical Research Council grant: MR/S025065/1. ACV acknowledges the financial support from the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/S001506/1) and the UKRI / EH HORIZON program (10053515 (101057390—HappyMums). The work (at King’s College London) was also supported by MRC Centre grant (MR/N026063/1). MET acknowledges the Tier 2 Canada Research Chair in Neurobiology of Aging and Cognition. All authors declare no competing interests.en_US
dc.identifier.citationMatuleviciute, R., Akinluyi, E. T., Muntslag, T. A. O., Dewing, J. M., Long, K. R., Vernon, A. C., Tremblay, M-E., & Menassa, D. A. (2023). Microglial contribution to the pathology of neurodevelopmental disorders in humans. Acta Nuropathologica, 146, 663-683. https://doi.org/10.1007/s00401-023-02629-2en_US
dc.identifier.urihttps://doi.org/10.1007/s00401-023-02629-2
dc.identifier.urihttp://hdl.handle.net/1828/15811
dc.language.isoenen_US
dc.publisherActa Neuropathologicaen_US
dc.subjectHuman microglia
dc.subjectNeurodevelopmental disorders
dc.subjectAutism spectrum conditions
dc.subjectSchizophrenia
dc.subjectSpatial transcriptomics
dc.subjectNeurodevelopmental models
dc.subjectHuman-induced pluripotent stem cells
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleMicroglial contribution to the pathology of neurodevelopmental disorders in humansen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
matuleviciute_rugile_ActaNeuropathol_2023.pdf
Size:
4.48 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.