Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

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dc.contributor.authorGarofalo, Stefano
dc.contributor.authorCocozza, Germana
dc.contributor.authorMormino, Alessandro
dc.contributor.authorBernardini, Giovanni
dc.contributor.authorRusso, Eleonora
dc.contributor.authorIelpo, Donald
dc.contributor.authorAndolina, Diego
dc.contributor.authorVentura, Rossella
dc.contributor.authorMartinello, Katiuscia
dc.contributor.authorRenzi, Massimiliano
dc.contributor.authorFucile, Sergio
dc.contributor.authorLaffranchi, Mattia
dc.contributor.authorMortari, Eva Piano
dc.contributor.authorCarsetti, Rita
dc.contributor.authorSciumè, Giuseppe
dc.contributor.authorSozzani, Silvano
dc.contributor.authorSantoni, Angela
dc.contributor.authorTremblay, Marie-Ève
dc.contributor.authorRansohoff, Richard M.
dc.contributor.authorLimatola, Cristina
dc.date.accessioned2024-01-25T22:17:30Z
dc.date.available2024-01-25T22:17:30Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.descriptionThe authors thank G. Peruzzi, Flow Cytometry Facility - Center for Life Nano- & Neuro-Science of Istituto Italiano di Tecnologia (IIT), for sorting experiment. We thank P. Ratano and R. Molfetta for excellent technical assistance, S. Di Angelantonio, M.K. St-Pierre and F.G. Ibáñez for revising the manuscript.en_US
dc.description.abstractThe mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in themeningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipS.G. was supported by A0112E0073 Funding Source: Regione Lazio POR FSE 2014-2020 PRATT25118; NextGenerationEU” DD.3175/2021 E DD. 3138/2021 CN_3: National Center for Gene Therapy and Drugs based on RNA Technology Codice Progetto CN 00000041; RFGR-2021-12372494. G.C. was supported by NextGenerationEU” DD.3175/2021 E DD. 3138/2021 CN_3: National Center for Gene Therapy and Drugs based on RNA Technology Codice Progetto CN 00000041. C.L. was supported by PRIN 2020: 2020Z73J5A; AIRC 2019: IG-23010; RF-2018-12366215; the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 952455; EpiEpiNet; Ministero Salute Progetto PAN HUB T4-AN-07. M.E.T. is a Tier 2 Canada Research Chair in Neurobiology of Aging and Cognition. M.L.was supported by AIRC fellowship for Italy 2020–25307.en_US
dc.identifier.citationGarofalo, S., Cocozza, G., Mormino, A., Bernardini, G., Russo, E., Ielpo, D., ... Limatola, C. (2023). Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine. Nature Communications, 14, 3103. https://doi.org/10.1038/s41467-023-38899-3en_US
dc.identifier.urihttps://doi.org/10.1038/s41467-023-38899-3
dc.identifier.urihttp://hdl.handle.net/1828/15890
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.subject.departmentSchool of Medical Sciences
dc.titleNatural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholineen_US
dc.typeArticleen_US

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