Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions

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dc.contributor.authorCheema, Manjinder S.
dc.contributor.authorGood, Katrina V.
dc.contributor.authorKim, Bohyun
dc.contributor.authorSoufari, Heddy
dc.contributor.authorO'Sullivan, Connor
dc.contributor.authorFreeman, Melissa E.
dc.contributor.authorStefanelli, Gilda
dc.contributor.authorCasas, Ciro Rivera
dc.contributor.authorZengeler, Kristine E.
dc.contributor.authorKennedy, Andrew J.
dc.contributor.authorLopez, Jose Maria Eirin
dc.contributor.authorHoward, Perry L.
dc.contributor.authorZovkic, Iva B.
dc.contributor.authorShabanowitz, Jeffrey
dc.contributor.authorDryhurst, Deanna D.
dc.contributor.authorHunt, Donald F.
dc.contributor.authorMackereth, Cameron D.
dc.contributor.authorAusió, Juan
dc.date.accessioned2020-07-06T16:49:28Z
dc.date.available2020-07-06T16:49:28Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractThe replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage to chromosome segregation, replication, and transcription. However, its functional involvement in gene expression is controversial. Moreover, the variant in several groups of metazoan organisms consists of two main isoforms (H2A.Z-1 and H2A.Z-2) that differ in a few (3–6) amino acids. They comprise the main topic of this review, starting from the events that led to their identification, what is currently known about them, followed by further experimental, structural, and functional insight into their roles. Despite their structural differences, a direct correlation to their functional variability remains enigmatic. As all of this is being elucidated, it appears that a strong functional involvement of isoform variability may be connected to development.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by grants from the Canadian Institutes of Health Research; (CIHR grant MOP-130417) to J.A. H.S. was supported with a PhD fellowship co-financed by Inserm and the Aquitaine regional government. J.M.E.L. was supported by grants from the National Science Foundation 1810981 and 1921402.en_US
dc.identifier.citationCheema, M. S., Good, K. V., Kim, B., Soufari, H., O’Sullivan, C., Freeman, M. E., … & Ausió, J. (2020). Deciphering the enigma of the histone H2A.Z-1/H2A.Z-2 isoforms: Novel insights and remaining questions. Cells, 9(5). https://doi.org/10.3390/cells9051167en_US
dc.identifier.urihttps://doi.org/10.3390/cells9051167
dc.identifier.urihttp://hdl.handle.net/1828/11896
dc.language.isoenen_US
dc.publisherCellsen_US
dc.subjectreplication dependent (RD) and replication independent (RI) histone variants
dc.subjectH2A.Z-1 and H2A.Z-2
dc.subjectevolution
dc.subjectNMR
dc.subjecttranscription
dc.subjectspermatogenesis
dc.subjectdevelopment
dc.subject.departmentDepartment of Microbiology and Biochemistry
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleDeciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questionsen_US
dc.typeArticleen_US

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