SpaceOAR© hydrogel rectal dose reduction prediction model: a decision support tool

Simple item page
dc.contributor.authorPaetkau, Owen
dc.contributor.authorGagne, Isabelle M.
dc.contributor.authorAlexander, Abraham
dc.date.accessioned2020-07-06T17:22:04Z
dc.date.available2020-07-06T17:22:04Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractProstate cancer external beam radiation therapy can result in toxicity due to organ at risk (OAR) dose, potentially impairing quality of life. A polyethylene glycol‐based spacer, SpaceOAR© hydrogel (SOH), implanted between prostate gland and rectum may significantly reduce dose received by the rectum and hence risk of rectal toxicity. SOH implant is not equally effective in all patients. Determining patients in which the implant will offer most benefit, in terms of rectal dose reduction, allows for effective management of SOH resources. Several factors have been shown to be correlated with reduction in rectal dose including distance between rectum and planning treatment volume (PTV), volume of rectum in the PTV, and change in rectum volume pre‐ to post‐SOH. Several of these factors along with other pre‐SOH CT metrics were able to predict reduction in rectal dose associated with SOH implant. Rectal V55Gy metric, was selected as the dose level of interest in the context of 60 Gy in 20 fraction treatment plans. Models were produced to predict change in RV55Gy and pre‐SOH hydrogel RV55Gy. These models offered R‐squared between 0.81 and 0.88 with statistical significance in each model. Applying an urn:x-wiley:15269914:media:acm212860:acm212860-math-0001 = 3% lower limit of pre‐SOH RV55 Gy and an urn:x-wiley:15269914:media:acm212860:acm212860-math-0002 = 3.5% lower limit on change in RV55 Gy, retained 60% of patients experiencing the largest rectal dose reduction from the hydrogel. This may offer a clinically useful tool in deciding which patients should receive SOH implant given limited resources. Predictive models, nomograms, and a workflow diagram were produced for clinical management of SOH implant.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors acknowledge Island Prostate Center for providing funding for SpaceOAR© hydrogel units. One author acknowledge Natural Sciences and Engineering Research Council of Canada (NSERC) for providing funding for this research.en_US
dc.identifier.citationPaetkau, O., Gagne, I. M., & Alexander, A. (2020). SpaceOAR© hydrogel rectal dose reduction prediction model: a decision support tool. Journal of Applied Clinical Medical Physics, 21(6), 15-25. https://doi.org/10.1002/acm2.12860.en_US
dc.identifier.urihttps://doi.org/10.1002/acm2.12860
dc.identifier.urihttp://hdl.handle.net/1828/11907
dc.language.isoenen_US
dc.publisherJournal of Applied Clinical Medical Physicsen_US
dc.subjectdecision support tool
dc.subjectlinear modeling
dc.subjectrectal dose
dc.subjectSpaceOAR hydrogel
dc.subject.departmentDepartment of Physics and Astronomy
dc.titleSpaceOAR© hydrogel rectal dose reduction prediction model: a decision support toolen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Paetkau_Owen_JApplClinMedPhys_2020.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.