Rethinking dog domestication by integrating genetics, archeology, and biogeography

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dc.contributor.authorLarson, Greger
dc.contributor.authorKarlsson, Elinor K.
dc.contributor.authorPerri, Angela
dc.contributor.authorWebster, Matthew T.
dc.contributor.authorHo, Simon Y. W.
dc.contributor.authorPeters, Joris
dc.contributor.authorStahl, Peter W.
dc.contributor.authorPiper, Philip J.
dc.contributor.authorLingaas, Frode
dc.contributor.authorFredholm, Merete
dc.contributor.authorComstock, Kenine E.
dc.contributor.authorModiano, Jamie F.
dc.contributor.authorSchelling, Claude
dc.contributor.authorAgoulnik, Alexander I.
dc.contributor.authorLeegwater, Peter A.
dc.contributor.authorDobney, Keith
dc.contributor.authorVigne, Jean-Denis
dc.contributor.authorVila, Carles
dc.contributor.authorAndersson, Leif
dc.contributor.authorLindblad-Toh, Kerstin
dc.date.accessioned2017-08-09T16:39:41Z
dc.date.available2017-08-09T16:39:41Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.description.abstractThe dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called “ancient” breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog’s wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipG.L. is currently a Research Councils United Kingdom Academic Fellow and was supported by a European Molecular Biology Organization postdoctoral fellowship; K.L.-T. is a European Young Investigator award recipient funded by the European Science Foundation, and was supported by grants from the Swedish Research Council; and A.P. was supported by the British Association for Japanese Studies.en_US
dc.identifier.citationLarson, G., Karlsson, E.K., Perri, A., Webster, M.T., Ho, S.Y.W., Peters, J., … Lindblad- Toh, K. (2012). Rethinking dog domestication by integrating genetics, archeology, and biogeography. Proceedings of the National Academy of Sciences of the United States of America, (109), 8878-8883. doi:10.1073/pnas.1203005109en_US
dc.identifier.urihttp://www.pnas.org/cgi/doi/10.1073/pnas.1203005109
dc.identifier.urihttp://hdl.handle.net/1828/8411
dc.language.isoenen_US
dc.publisherProceedings of the National Academy of Sciences of the United States of America (PNAS)en_US
dc.subjectgenomics
dc.subjectphylogeography
dc.subject.departmentDepartment of Anthropology
dc.titleRethinking dog domestication by integrating genetics, archeology, and biogeographyen_US
dc.typeArticleen_US

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