A review and meta-analysis of anti-ribosomal P autoantibodies in systemic lupus erythematosus

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dc.contributor.authorChoi, May Y.
dc.contributor.authorFitzPatrick, Rachael D.
dc.contributor.authorBuhler, Katherine
dc.contributor.authorMahler, Michael
dc.contributor.authorFritzler, Marvin J.
dc.date.accessioned2020-03-09T17:15:51Z
dc.date.available2020-03-09T17:15:51Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractThe discovery of autoantibodies to ribosomal proteins (anti-RibP) dates back more than fifty years when antibodies to ribosomes were identified in systemic lupus erythematosus (SLE) sera. Over the years, anti-RibP autoantibodies have been the subject of extensive study and became known as a highly specific biomarker for the diagnosis of SLE and were associated with neuropsychiatric SLE (NPSLE), lupus nephritis (LN) and hepatitis (LH). As demonstrated by studies on cultured human cells and of murine models, there is evidence to suggest that anti-RibP may have a pathogenic role in LN and NPSLE. Despite a wealth of evidence, in comparison to other SLE autoantibodies such as anti-Sm and anti-dsDNA, anti-RibP has not been included in classification criteria for SLE. A significant challenge is the variability of assays used to detect anti-RibP, including the antigens and diagnostic platforms employed. This may account for the marked variation in frequencies (10–47%) in SLE and its association with clinical and demographic features reported in SLE cohorts. We performed a systematic literature review and meta-analysis to help clarify its prevalence, various clinical and serological associations in SLE based on the different RibP antigens and assay platforms used.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipMJF has received gifts in kind in the form of diagnostic kits from Inova Diagnostics (San Diego, CA, USA). RDF was a University of Victoria Co-op trainee and received support from Mitogen Advanced Diagnostics Laboratory. The funding sources had no role in the design of the study, analysis of the data, preparation of the manuscript and decision to submit for publication.en_US
dc.identifier.citationChoi, M.Y., FitzPatrick, R.D., Buhler, K., Mahler, M. & Fritzler, M.J. (2020). A review and meta-analysis of anti-ribosomal P autoantibodies in systemic lupus erythematosus. Autoimmunity Reviews, 19(3), 102463. https://doi.org/10.1016/j.autrev.2020.102463en_US
dc.identifier.urihttps://doi.org/10.1016/j.autrev.2020.102463
dc.identifier.urihttp://hdl.handle.net/1828/11618
dc.language.isoenen_US
dc.publisherAutoimmunity Reviewsen_US
dc.subject.departmentDepartment of Microbiology and Biochemistry
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleA review and meta-analysis of anti-ribosomal P autoantibodies in systemic lupus erythematosusen_US
dc.typeArticleen_US

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