BioAge: Toward A Multi-Determined, Mechanistic Account of Cognitive Aging

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dc.contributor.authorDeCarlo, C.A.
dc.contributor.authorTuokko, H.A.
dc.contributor.authorWilliams, D.
dc.contributor.authorDixon, R.A.
dc.contributor.authorMacDonald, Stuart W.S.
dc.date.accessioned2021-08-20T19:51:54Z
dc.date.available2021-08-20T19:51:54Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.description.abstractThe search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by grants from the Natural Sciences and Engineering Research Council of Canada (418676–2012) and a Scholar Career Investigator Award from the Michael Smith Foundation for Health Research to S.W.S. MacDonald, the National Institutes of Health/National Institute on Aging (R01 AG 008235) to R.A. Dixon, and a doctoral training award from the Alzheimer’s Society of Canada to C. A. DeCarlo.en_US
dc.identifier.citationDeCarlo, C.A., Tuokko, H.A., Willliams, D., Dixon, R.A., MacDonald, S.W.S. (2014). BioAge: Toward A Multi-Determined, Mechanistic Account of Cognitive Aging. Ageing Research Review, 18, 95-105. https://doi.org/10.1016/j.arr.2014.09.003en_US
dc.identifier.urihttps://doi.org/10.1016/j.arr.2014.09.003
dc.identifier.urihttp://hdl.handle.net/1828/13291
dc.language.isoenen_US
dc.publisherAeging Research Reviewen_US
dc.subjectBiological Age
dc.subjectOxidative Stress
dc.subjectVascular Health
dc.subjectEarly Identification
dc.subjectCognitive Aging
dc.subjectInflammation
dc.subjectInstitute on Aging and Lifelong Health
dc.subject.departmentDepartment of Psychology
dc.titleBioAge: Toward A Multi-Determined, Mechanistic Account of Cognitive Agingen_US
dc.typeArticleen_US

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