Regulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Disease

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dc.contributor.authorSwayne, Leigh Anne
dc.contributor.authorBoyce, Andrew K. J.
dc.date.accessioned2018-11-20T17:28:07Z
dc.date.available2018-11-20T17:28:07Z
dc.date.copyright2017en_US
dc.date.issued2017
dc.description.abstractPannexin 1 (Panx1) channels are widely recognized for their role in ATP release, and as follows, their function is closely tied to that of ATP-activated P2X7 purinergic receptors (P2X7Rs). Our recent work has shown that extracellular ATP induces clustering of Panx1 with P2X7Rs and their subsequent internalization through a non-canonical cholesterol-dependent mechanism. In other words, we have demonstrated that extracellular ATP levels can regulate the cell surface expression of Panx1. Here we discuss two situations in which we hypothesize that ATP modulation of Panx1 surface expression could be relevant for central nervous system function. The first scenario involves the development of new neurons in the ventricular zone. We propose that ATP-induced Panx1 endocytosis could play an important role in regulating the balance of cell proliferation, survival, and differentiation within this neurogenic niche in the healthy brain. The second scenario relates to the spinal cord, in which we posit that an impairment of ATP-induced Panx1 endocytosis could contribute to pathological neuroplasticity. Together, the discussion of these hypotheses serves to highlight important outstanding questions regarding the interplay between extracellular ATP, Panx1, and P2X7Rs in the nervous system in health and disease.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipResearch in the Swayne lab is supported by operating grant support to LS from the Natural Sciences and Engineering Research Council (RGPIN-2017-03889), the Canadian Institutes of Health Research (MOP142215), The Scottish Rite Charitable Foundation of Canada (15118) and the University of Victoria Division of Medical Sciences. LS is also supported by a Michael Smith Foundation for Health Research and British Columbia Schizophrenia Society Foundation Scholar Award (5900), and is grateful for infrastructure support from the Canada Foundation for Innovation (29462), and the BC Knowledge Development Fund (804754). AB was awarded scholarships from NSERC (PGSD 459931-2014) and the University of Victoria (President's Research Scholarship, Dr. Howard E. Petch and Dr. Julius F. Schleicher Memorial Scholarships).en_US
dc.identifier.citationSwayne, L.A. & Boyce, A.K.J. (2017). Regulation of Pannexin 1 surface expression by extracellular ATP: Potential implications for nervous system function in health and disease. Frontiers in Cellular Neuroscience, 11, article 230. https://doi.org/10.3389/fncel.2017.00230en_US
dc.identifier.urihttps://doi.org/10.3389/fncel.2017.00230
dc.identifier.urihttp://hdl.handle.net/1828/10338
dc.language.isoenen_US
dc.publisherFrontiers in Cellular Neuroscienceen_US
dc.subjectPannexin 1
dc.subjectpurinergic signaling
dc.subjectP2X7 receptor
dc.subjectATP
dc.subjectventricular zone
dc.subjectpain
dc.subjectIsland Medical Program
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleRegulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Diseaseen_US
dc.typeArticleen_US

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