Effect of depletion of noradrenaline on cortical kindling
Date
1982
Authors
Altman, Irwin Morris
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Abstract
The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline (arbitrarily defined as greater than 80%) significantly facilitated the rate of kindling of cortico-generalized seizures. In contrast, a group of 6-OHDA-treated rats that showed minimal depletion of noradrenaline (arbitrarily defined as 80% or less) appeared to develop generalized seizures at a slower rate than controls.
The present findings extend previous observations that 6-OHDA-induced depletion of noradrenaline facilitates amygdaloid kindling, by demonstrating that cortical kindling is similarly affected.