Effect of depletion of noradrenaline on cortical kindling

Simple item page
dc.contributor.authorAltman, Irwin Morrisen_US
dc.date.accessioned2024-08-12T19:30:34Z
dc.date.available2024-08-12T19:30:34Z
dc.date.copyright1982en_US
dc.date.issued1982
dc.degree.departmentDepartment of Psychology
dc.degree.levelMaster of Science M.Sc.en
dc.description.abstractThe role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline (arbitrarily defined as greater than 80%) significantly facilitated the rate of kindling of cortico-generalized seizures. In contrast, a group of 6-OHDA-treated rats that showed minimal depletion of noradrenaline (arbitrarily defined as 80% or less) appeared to develop generalized seizures at a slower rate than controls. The present findings extend previous observations that 6-OHDA-induced depletion of noradrenaline facilitates amygdaloid kindling, by demonstrating that cortical kindling is similarly affected.
dc.format.extent46 pages
dc.identifier.urihttps://hdl.handle.net/1828/16950
dc.rightsAvailable to the World Wide Weben_US
dc.titleEffect of depletion of noradrenaline on cortical kindlingen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ALTMAN_Irwin_Morris_MSC_1982_172777.pdf
Size:
5.83 MB
Format:
Adobe Portable Document Format
Download

Collections

Electronic Theses and Dissertations (ETD)
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.