Next generation high resolution perovskite direct conversion detector: Monte Carlo design optimisation and virtual clinical trial

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dc.contributor.authorO'Connell, Jericho
dc.contributor.authorKundu, S
dc.contributor.authorSaidaminov, Makhsud I.
dc.contributor.authorBazalova-Carter, M
dc.date.accessioned2023-03-30T20:58:49Z
dc.date.available2023-03-30T20:58:49Z
dc.date.copyright2023en_US
dc.date.issued2023-01-11
dc.description.abstractWe implement virtual clinical integration of next-generation perovskite detectors into common x-ray imaging devices. This was achieved by performing Monte Carlo (MC) optimisation of the design and benchmarking of low cost, high spatial resolution, direct conversion perovskite crystal x-ray flat panel imagers for a next generation of breast-, MV-, and kV-cone beam CT detectors. Semiconductor methylammonium lead bromide perovskite crystals energy deposition efficiencies calculated in TOPAS were benchmarked against four common detector materials for twelve detector crystal thicknesses between 40 to 15 mm and ten beam energies ranging from 20 keV to 6 MeV. Based on these simulations, Koning's dedicated breast CT, and Varian's Truebeam kV- and MV-cone beam CT systems were designated as suitable applications for perovskite detectors. System specific Fastcat hybrid MC cone beam CT image simulation was subsequently used to optimise the perovskite detector design and conduct virtual clinical trials. Device-specific optimal perovskite crystal thicknesses were calculated to be 0.30, 0.86, and 1.99 mm for Koning breast CT and Truebeam kV- and MV-cone beam CT systems, respectively. Replacing the current detectors on these machines with low cost perovskite crystal detectors could be advantageous as it would simultaneously yield 12.1%, 9.5% and 86.1% improvements in detective quantum efficiency as well as increases in contrast to noise ratio in brain, lung, and bone tissues.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationO’Connell, J., Kundu, S., Saidaminov, M., & Bazalova-Carter, M. (2023). Next generation high resolution perovskite direct conversion detector: Monte Carlo design optimisation and virtual clinical trial. Physics in Medicine & Biology, 68(2), 025016. https://doi.org/10.1088/1361-6560/acae15en_US
dc.identifier.urihttps://doi.org/10.1088/1361-6560/acae15
dc.identifier.urihttp://hdl.handle.net/1828/14930
dc.language.isoenen_US
dc.publisherPhysics in Medicine & Biologyen_US
dc.subjectperovskite
dc.subjectCT
dc.subjectCBCT
dc.subjectVCT
dc.subjectdetector
dc.subjectmammography
dc.subject.departmentDepartment of Chemistry
dc.titleNext generation high resolution perovskite direct conversion detector: Monte Carlo design optimisation and virtual clinical trialen_US
dc.typeArticleen_US

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